Ultraviolet-B Light Therapy and Allogeneic Stem Cell Transplantation in Treating Patients With He… (NCT00068523) | Clinical Trial Compass
CompletedNot Applicable
Ultraviolet-B Light Therapy and Allogeneic Stem Cell Transplantation in Treating Patients With Hematologic Malignancies
United States10 participantsStarted 2003-06
Plain-language summary
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy. Sometimes the transplanted cells from a donor are rejected by the body's normal cells. Ultraviolet-B light therapy given before and after allogeneic stem cell transplantation may help prevent this from happening.
PURPOSE: Clinical trial to study the effectiveness of combining ultraviolet-B light therapy with allogeneic stem cell transplantation in treating patients who have hematologic malignancies.
Who can participate
Age range
18 Years – 120 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed diagnosis of any of the following hematologic malignancies:
* Acute myeloid leukemia (AML) meeting any of the following criteria:
* First complete remission with high-risk karyotype
* Translocations t(15;17) allowed only if failed first-line induction therapy OR molecular evidence of persistent disease exists
* Translocations t(8;21) and inv(16) allowed only if failed first-line induction therapy
* Second or subsequent complete remission
* Minimal residual disease\*
* Acute lymphoblastic leukemia meeting any of the following criteria:
* Failed induction therapy and has minimal residual disease\* by salvage therapy
* First complete remission with high-risk karyotype (e.g., t\[4;11\] or t\[9;22\])
* Relapsed disease allowed provided a second or subsequent complete remission or minimal residual disease\* is achieved
* Chronic myelogenous leukemia meeting any of the following criteria:
* Persistent or relapsed disease after 1 year of imatinib mesylate therapy
* Accelerated phase or blast crisis
* Blast crisis allowed after reinduction chemotherapy places disease in chronic phase
* Myelodysplastic syndromes meeting any of the following criteria:
* Refractory to medical management
* Cytogenetic abnormalities predictive of transformation into acute leukemia, including 5q-, 7q-, monosomy 7 and trisomy 8, or evidence of evolution to AML (e.g., refractory anemia…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Study the effectiveness of combining ultraviolet-B light therapy with allogeneic stem cell transplantation in treating patients who have hematologic malignancies.
Timeframe: Patients are followed at least monthly for 3 months and then at 6, 12, 18, and 24 months.