Voriconazole in Preventing Fungal Infections in Children With Neutropenia After Chemotherapy

DISEASE CHARACTERISTICS: * Expected to develop neutropenia (absolute neutrophil count less than 500/mm\^3) lasting for more than 10 days after chemotherapy for 1 of the following conditions: * Leukemia * Lymphoma * Aplastic anemia * Preparation for a bone marrow or stem cell transplantation * Requiring treatment for the prevention of systemic fungal infection PATIENT CHARACTERISTICS: Age * 2 to 11 Performance status * Not specified Life expectancy * More than 3 months Hematopoietic * See Disease Characteristics Hepatic * AST and ALT no greater than 5 times upper limit of normal (ULN) * Bilirubin no greater than 5 times ULN Renal * Creatinine clearance at least 30 mL/min Cardiovascular * No cardiac arrhythmia Other * Not pregnant or nursing * Negative pregnancy test * No severe hypokalemia (potassium less than 3.2 mmol/L) * No prior hypersensitivity to or severe intolerance of azole antifungal agents * No other concurrent condition that would preclude study therapy PRIOR CONCURRENT THERAPY: Biologic therapy * See Disease Characteristics Chemotherapy * See Disease Characteristics Endocrine therapy * Not specified Radiotherapy * Not specified Surgery * Not specified Other * At least 24 hours since prior use of any of the following: * Terfenadine * Pimozide * Quinidine * Astemizole * Cisapride * Omeprazole * More than 14 days since prior use of any of the following: * Rifampin * Rifabutin * Carbamazepine * Phenytoin …