Alanosine in Treating Patients With Cancer (NCT00062283) | Clinical Trial Compass
CompletedPhase 2
Alanosine in Treating Patients With Cancer
United StatesStarted 2003-03
Plain-language summary
RATIONALE: Drugs used in chemotherapy such as alanosine use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: This phase II trial is studying how well alanosine works in treating patients with soft tissue sarcoma, sarcoma of the bone, mesothelioma, non-small cell lung cancer, or pancreatic cancer.
Who can participate
Age range
13 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically or cytologically confirmed malignancy of any of the following types:
* Soft-tissue sarcoma
* High grade
* Chemotherapy naïve or progressive or metastatic after no more than 2 prior cytotoxic treatment regimens (not including adjuvant therapy)
* Sarcoma of the bone (including osteosarcoma\* and chondrosarcoma)
* High grade
* Progressive or recurrent after no more than 2 prior cytotoxic treatment regimens
* No newly diagnosed or chemotherapy naïve disease NOTE: \*Prior treatment with cisplatin and doxorubicin required
* Mesothelioma
* Unresectable
* Chemotherapy naïve or progressive after no more than 1 prior cytotoxic chemotherapy regimen
* Not amenable to curative treatment with surgery
* Evidence of gross unresectability includes, but is not limited to, direct extension into the chest wall, mediastinal or hilar lymphadenopathy, pulmonary or cardiac function that is inadequate to tolerate resection, and sarcomatoid or mixed histology
* Non-small cell lung cancer
* Stage III with malignant pleural or pericardial effusion, stage IV, or progressive after no more than 2 prior cytotoxic chemotherapy regimens
* No newly diagnosed or chemotherapy naïve disease
* Pancreatic cancer
* Stage IV adenocarcinoma after no more than 1 prior cytotoxic treatment regimen
* No newly diagnosed or chemotherapy naïve disease
* No Ewing's sarcoma of the soft tissue or bone
* Documented a…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.