Adjuvant Radiation Therapy in Treating Patients With Resected Desmoplastic Melanoma

Inclusion Criteria * Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, or 2 * Pathologically proven DM \>= 1 mm in depth or locally recurrent DM; recurrent tumor is defined as a tumor found =\< 2 cm from the previous excision or within the surgical bed (which includes the extent of previous skin flaps) * DM resected with pathologically negative margins; acceptable surgery includes standard wide local excision and Moh's surgery * Tumors on the trunk proximal extremities need to have a \>= 2 cm negative margin; tumors located on the head and neck and distal extremities will have an attempt at 2 cm negative margins but due to location and subsequent concern regarding cosmesis a margin \< 2 cm will be acceptable if margin is negative * Margins from tumors resected using the Moh's technique will be accepted if negative and best approximation of tumor width will be made * Radiation therapy (RT) is to begin =\< 8 weeks after definitive surgical resection * Adjuvant systemic therapy (immunotherapy or chemotherapy) must be postponed until irradiation is completed Exclusion Criteria * Previous irradiation to the same site * Non-healing surgical wound * Active infection at the surgical site * Evidence of metastatic disease; local nodal disease is still eligible for the trial * Life expectancy \< 1 year * Melanoma with focally desmoplastic features, in which the desmoplastic melanoma is not the predominant histologic pattern of the tumor, will be excluded; n…