Interleukin-2 and Stem Cell Factor in Treating Patients With AIDS or AIDS-Related Cancer (NCT00058045) | Clinical Trial Compass
CompletedPhase 1
Interleukin-2 and Stem Cell Factor in Treating Patients With AIDS or AIDS-Related Cancer
United States1 participantsStarted 2002-08
Plain-language summary
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill cancer cells. Stem cell factor may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's immune system recover from the side effects of cancer therapy.
PURPOSE: Phase I trial to study the effectiveness of combining interleukin-2 with stem cell factor in treating patients who have AIDS or AIDS-related cancer.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Diagnosis of HIV-1 by ELISA, Western blot, polymerase chain reaction, or other documentation
* Must have had 1 of the following AIDS-defining illnesses:
* Opportunistic infection
* Opportunistic malignancy (excluding CNS involvement)
* CD4 T-cell count less than 200/mm\^3 (but currently greater than 20/mm\^3)
* Receiving antiretroviral therapy
* No concurrent Kaposi's sarcoma
* Prior Kaposi's sarcoma in complete response allowed
PATIENT CHARACTERISTICS:
Age
* 18 and over
Performance status
* Karnofsky 80-100%
Life expectancy
* Not specified
Hematopoietic
* Absolute granulocyte count greater than 1,000/mm\^3\*
* Hemoglobin at least 10 g/dL\*
* Platelet count greater than 50,000/mm\^3\* NOTE: \*Transfusions and growth factors allowed in order to increase or maintain counts
Hepatic
* No major hepatic dysfunction evidenced by encephalopathy, ascites, or varices
* Bilirubin no greater than 2 mg/dL
* INR no greater than 1.5
Renal
* Not specified
Cardiovascular
* No prior angioedema
* No uncontrolled hypertension (i.e., diastolic blood pressure greater than 115 mmHg)
* No unstable angina
* No New York Heart Association class III or IV heart disease
* No congestive heart failure
* No coronary angioplasty within the past 6 months
* No myocardial infarction within the past 6 months
* No uncontrolled atrial or ventricular cardiac arrhythmia
Pulmonary
* No history of seasonal or recurrent asthma within the past 10 years
* No concurre…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.