Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue Sarcoma (NCT00053794) | Clinical Trial Compass
CompletedPhase 2
Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue Sarcoma
Canada17 participantsStarted 2003-06-09
Plain-language summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of perifosine in treating patients who have metastatic or locally advanced soft tissue sarcoma.
Who can participate
Age range18 Years – 120 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed metastatic or locally advanced soft tissue sarcoma that is incurable by standard therapies, including any of the following types:
* Uterine sarcomas
* Mixed mesodermal
* Leiomyosarcoma
* Endometrial stromal sarcoma
* Alveolar soft part sarcoma
* Angiosarcoma/lymphangiosarcoma
* Fibrosarcoma
* Hemangiopericytoma
* Leiomyosarcoma
* Liposarcoma
* Malignant fibrous histiocytoma
* Neurogenic sarcoma
* Pleomorphic rhabdomyosarcoma
* Synovial sarcoma
* Unclassifiable sarcoma
* Undifferentiated sarcoma
* Excluded diseases include the following:
* Bone sarcomas (e.g., osteosarcoma, Ewing's sarcoma, chondrosarcoma)
* Embryonal rhabdomyosarcoma
* Carcinosarcoma
* Kaposi's sarcoma
* Malignant mesothelioma
* Neuroblastoma
* Gastrointestinal stromal tumor
* At least 1 unidimensionally measurable site of disease (outside the previously irradiated area) defined as:
* At least 20 mm by x-ray or physical exam
* At least 10 mm by spiral CT scan
* At least 20 mm by non-spiral CT scan NOTE: Bone lesions are not considered measurable
NOTE: Patients whose sole site of disease is within a previously irradiated area are allowed if there is evidence of progression or new lesions in the irradiated field
* No known brain metastases
PATIENT CHARACTERISTICS:
Age
* 18 and over
Performance status
* ECOG 0-2
Life expectancy
* At least 12 weeks
Hematopoietic
* Absolute granulocyte coun…