Blood Collection for Research Related to Certain Diseases Involving Blood Vessels (NCT00047996) | Clinical Trial Compass
By InvitationNot Applicable
Blood Collection for Research Related to Certain Diseases Involving Blood Vessels
United States2,000 participantsStarted 2002-11-04
Plain-language summary
The collection of human specimens from both patients and healthy volunteers is necessary for the development of laboratory assays to further basic and clinical research studies. This protocol defines the purposes for which specimens will be collected and establishes general conditions under which sample collection will be performed.
Who can participate
Age range
18 Years – 100 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
* INCLUSION CRITERIA:
Males or females of age 18 years and older can be included in the study.
EXCLUSION CRITERIA:
Individuals without sickle cell disease or other chronic anemias who wish to donate blood will be excluded if the hemoglobin is less than 10 g/dL for women or less than 12g/dL for men.
Individuals with sickle cell disease or other chronic anemias will be excluded from donating blood samples if the hemoglobin is less than 6 g/dL.
A participant s most recent CBC result, obtained in the past 12 months, will be used to determine eligibility.
There are no exclusion criteria for participants donating urine.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this study is enrolling by invitation only, is my case or my child's case the kind that researchers at this center would consider, and how would a referral or invitation actually happen?
2This trial is focused on collecting blood samples to study nitric oxide, inflammation, and how blood vessels function in sickle cell disease — does participating mean any changes to my current treatment, or is it purely observational?
3What exactly would blood collection involve in terms of how much blood is drawn, how often, and over what period of time, and are there any risks specific to someone with sickle cell disease having additional blood drawn?
4Since this research is studying the underlying biology of sickle cell disease rather than testing a new treatment, how might the findings eventually benefit patients like me, and is there any direct benefit to me personally for participating?
5Are there other active trials or standard-of-care treatments I should be considering alongside or instead of joining this study, especially if the goal here is scientific research rather than improving my symptoms right now?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
evaluating the role of nitric oxide, inflammatory mediators, and endothelial function in inflammatory diseases of the vasculature such as sickle cell disease, coronary artery disease, pulmonary vascular or advanced lung disease, malaria, and sep...
Trial details
NCT IDNCT00047996
SponsorNational Heart, Lung, and Blood Institute (NHLBI)