Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer (NCT00045006) | Clinical Trial Compass
CompletedPhase 1
Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer
United StatesStarted 2001-07
Plain-language summary
RATIONALE: Suberoylanilide hydroxamic acid may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth.
PURPOSE: Phase I trial to study the effectiveness of suberoylanilide hydroxamic acid in treating patients who have advanced cancer.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* One of the following diagnoses:
* Histologically confirmed advanced primary or metastatic solid tumor, including, but not limited to, the following:
* Androgen-independent prostate cancer
* Breast cancer
* Ovarian cancer
* Head and neck cancer
* Non-small cell lung cancer
* Bladder cancer
* Kidney cancer
* Diagnosis of lymphoma, multiple myeloma, leukemia, or myelodysplastic syndromes (MDS), including, but not limited to, the following:
* Intermediate-grade or follicular non-Hodgkin's lymphoma
* Hodgkin's lymphoma
* Patients with lymphoma or multiple myeloma must be ineligible for peripheral blood stem cell transplantation
* For patients with solid tumors (except prostate cancer):
* Disease progression based on development of new lesions or an increase in pre-existing lesions
* Biochemical marker increase must not be sole criterion for disease progression
* For prostate cancer patients only:
* Disease progression based on rising prostate-specific antigen (PSA) values, transaxial imaging, or radionuclide scans
* Increase in disease-related symptoms must not be sole manifestation of progression
* Patients receiving an antiandrogen as part of first-line hormonal therapy must show disease progression off of the antiandrogen prior to study
* Biochemical progression (at least 25% increase over range of values) defined as 1 of the following:
* Rising PSA documented by at least 3 consecutive mea…