CompletedPhase 2

Brain Imaging and Retreatment Study of Persistent Lyme Disease

United States65 participantsStarted 1999-12

Plain-language summary

The purpose of this study is to determine whether patients with persistent memory problems after Lyme disease benefit from an additional longer course of IV antibiotic therapy; to use modern brain imaging technology to determine whether the problem in the central nervous system is primarily one of poor blood flow or one of impaired nerve cell functioning; and to try to identify biological markers prior to treatment that will identify patients who are more or less likely to respond to the study treatment.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion Criteria: Eligible participants must: * Be 18-65 years old * Have persistent problems with memory, verbal fluency, or attention after having contracted Lyme disease. * Be able to travel to New York for 4-5 evaluations over the course of one year. Travel costs for participants in need may be partially or fully reimbursable. * Have had a history of well-documented Lyme disease using the CDC's clinical criteria and a current positive IgG Western blot or PCR. * Have received, at some point in the past at least 3 weeks of IV antibiotic therapy for Lyme disease. Exclusion Criteria: Ineligible from participation are people with the following: * Other major medical or neurologic problems * Smoke more than 10 cigarettes a day * Uncontrolled high blood pressure * Allergy to ceftriaxone (Rocephin) * History of marked cocaine abuse Twenty healthy subjects are also being sought for the study.

Trial details

NCT IDNCT00037479

SponsorNational Institute of Neurological Disorders and Stroke (NINDS)

Sponsor typeNIH

Study typeINTERVENTIONAL

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