Peripheral Stem Cell Transplantation Followed By Infusion of White Blood Cells in Treating Patien… (NCT00024128) | Clinical Trial Compass
WithdrawnPhase 2
Peripheral Stem Cell Transplantation Followed By Infusion of White Blood Cells in Treating Patients With AIDS-Related Lymphoma
Stopped: Withdrawn prior to initiation.
0Started 2001-08
Plain-language summary
RATIONALE: Donor peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy. Sometimes the transplanted cells are rejected by the body's normal tissues. Treatment with donor white blood cells may prevent this from happening.
PURPOSE: Phase II trial to study the effectiveness of donor peripheral stem cell transplantation followed by infusions of donor white blood cells in treating patients who have AIDS-related lymphoma.
Who can participate
Age range65 Years
SexALL
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DISEASE CHARACTERISTICS:
* Diagnosis of Hodgkin's disease or non-Hodgkin's lymphoma
* Failed to achieve a complete remission with initial therapy OR
* Relapsed after initial therapy
* HIV-1 seropositive by Western Blot
* Measurable or evaluable (e.g., pleural fluid involvement) disease
* No leptomeningeal or parenchymal CNS involvement or active CNS leukemia
* HLA-A, B, or DR antigen matched or 1 antigen mismatched related donor available
* CD4 cell count greater than 100/mm3 (initial 12 patients) OR greater than 50/mm3 (subsequent patients)\*
* HIV RNA less than 110,000 copies/mL\* NOTE: \*Unless not receiving optimal anti-retroviral therapy as defined by current clinical standards
PATIENT CHARACTERISTICS:
Age:
* Physiologic 65 and under
Performance status:
* Karnofsky 70-100%
Life expectancy:
* Estimated disease-free survival less than 1 year
Hematopoietic:
* See Disease Characteristics
Hepatic:
* Bilirubin no greater than 2 mg/dL
* Alkaline phosphatase no greater than 3 times upper limit of normal (ULN)\*
* SGOT or SGPT no greater than 3 times ULN\*
* Hepatitis B surface antigen negative NOTE: \*Unless receiving indinavir
Renal:
* Creatinine no greater than 1.5 mg/dL
* Creatinine clearance at least 50 mL/min
Cardiovascular:
* No symptomatic congestive heart failure
* No angina pectoris
* No uncontrolled hypertension
* LVEF at least 45% by radionuclide ventriculography
Pulmonary:
* No severe chronic obstructive lung disease
* No symptomatic restrictiv…