Caspofungin Acetate in Treating Children With Fever and Neutropenia (NCT00020527) | Clinical Trial Compass
CompletedNot Applicable
Caspofungin Acetate in Treating Children With Fever and Neutropenia
United StatesStarted 2001-03
Plain-language summary
RATIONALE: Giving caspofungin acetate may be effective in preventing or controlling fever and neutropenia caused by chemotherapy or bone marrow transplantation.
PURPOSE: Clinical trial to study the effectiveness of caspofungin acetate in treating children who have fever and neutropenia caused by a weakened immune system.
Who can participate
Age range
2 Years – 17 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Immunocompromised with one or more of the following conditions:
* Leukemia, lymphoma, or other cancer
* Underwent bone marrow or peripheral blood stem cell transplantation
* Aplastic anemia
* Planned chemotherapy likely to incur more than 10 days of neutropenia
* Absolute neutrophil count no greater than 500/mm\^3 AND at least 1 recorded fever over 38.0 ° C within 24 hours of study
* No proven invasive fungal infection at time of study entry
* Superficial fungal infection (e.g., cutaneous fungal infection, thrush, or candidal vaginitis) treatable with topical antifungals allowed
PATIENT CHARACTERISTICS:
Age:
* 2 to 17
Performance status:
* Not specified
Life expectancy:
* At least 5 days
Hematopoietic:
* See Disease Characteristics
* Hemodynamically stable with no hemodynamic compromise
Hepatic:
* AST or ALT no greater than 3 times upper limit of normal (ULN)
* Alkaline phosphatase no greater than 5 times ULN (unless related to bony metastases or other suspected bony processes)
* INR no greater than 1.6 (4.0 if receiving anticoagulants)
* No acute hepatitis or cirrhosis
Renal:
* Not specified
Other:
* Functioning central venous catheter in place
* No other condition or concurrent illness that would preclude study
* No prior allergy, hypersensitivity, or serious reaction to echinocandin antifungals
* HIV negative
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception other tha…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.