Perifosine in Treating Patients With Refractory Solid Tumors or Hematologic Cancer (NCT00019656) | Clinical Trial Compass
CompletedPhase 1
Perifosine in Treating Patients With Refractory Solid Tumors or Hematologic Cancer
United StatesStarted 1999-08
Plain-language summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase I trial to study the effectiveness of perifosine in treating patients who have refractory solid tumors or hematologic cancer.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed solid tumor, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, myelodysplastic syndromes, or Hodgkin's lymphoma that has no effective standard therapeutic option but requires systemic therapy
* No history of CNS neoplasms
* For prostate cancer:
* Tumor progression during blockade of testicular and adrenal androgens
* At least 4 weeks since prior flutamide or other antiandrogens without disease improvement
* Leuprolide or other gonadotropin-releasing hormones should be maintained in patients without an orchiectomy
* Testosterone in the castrate range
* For breast cancer:
* At least 4 weeks since any prior hormonal therapy with evidence of disease progression
PATIENT CHARACTERISTICS:
Age:
* Over 18
Performance status:
* ECOG 0-2
Life expectancy:
* Not specified
Hematopoietic:
* Platelet count greater than 50,000/mm\^3
* Absolute granulocyte count greater than 500/mm\^3
* Hemoglobin at least 9.0 g/dL
Hepatic:
* Bilirubin no greater than 1.5 mg/dL
* SGOT and SGPT no greater than 2.5 times normal
Renal:
* Creatinine no greater than 1.5 mg/dL OR
* Creatinine clearance at least 60 mL/min
Cardiovascular:
* No history of unstable or newly diagnosed angina pectoris
* No myocardial infarction within the past 6 months
* No New York Heart Association class II-IV heart disease
Other:
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* HIV negative
* No…