Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant

Inclusion Criteria: * Patients with severe combined immunodeficiency syndrome: * SCID with presence of B lymphocytes * X-linked SCID (presence of B lymphocytes) * Autosomal recessive SCID * Patients with severe combined immunodeficiency syndrome: * SCID with absence of T and B lymphocytes * Patients with severe combined immunodeficiency syndrome: * Purine metabolite deficiencies, deficiencies of the purine metabolites * Adenosine deaminase (ADA) deficiency * Purine nucleoside phosphorylase (PNP) deficiency * DONOR: Related donor who is human leukocyte antigen (HLA) genotypically identical at least at one haplotype and may be genotypically or phenotypically identical for serological typing for HLA-A, B, C, and at the allele level for DRB1 and DQB1; related donors other than siblings must be matched at HLA-A, B, and C (at highest resolution available at the time of donor selection) and at DRB1 and DQB1 by deoxyribonucleic acid (DNA) typing; if more than one HLA-identical sibling is available, priority will be given to the oldest normal donor * DONOR: Unrelated donors who are prospectively matched for HLA-A, B, C, DRB1 and DQB1 by DNA typing at the highest resolution routinely available at the time of donor selection; only a single allele disparity will be allowed for HLA-A, B, or C as defined by high resolution typing Exclusion Criteria: * Patients with viral associated T cell immunodeficiency disorders, such as human immunodeficiency virus (HIV) *…