Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Mal… (NCT00008008) | Clinical Trial Compass
CompletedPhase 2
Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Malignant Glioma
United States40 participantsStarted 1997-09
Plain-language summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy with peripheral stem cell or bone marrow transplant may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells.
PURPOSE: This phase II trial is studying how well thiotepa followed by peripheral stem cell or bone marrow transplant works in treating patients with malignant glioma.
Who can participate
SexALL
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DISEASE CHARACTERISTICS:
* Histologically confirmed malignant glioma
* Primary or recurrent glioblastoma multiforme (including gliosarcoma) following surgery and radiotherapy or prior conventional chemotherapy (e.g., carmustine or procarbazine, vincristine, and lomustine)
* Recurrent or refractory anaplastic astrocytoma following any prior therapy (must be chemoresistant)
* Recurrent or refractory ependymoma or primitive neuroectodermal tumor (PNET) following any prior therapy
* Recurrent or refractory oligodendroglioma or oligoastrocytoma following any prior therapy (must be chemoresistant)
* Evaluable disease on gadolinium-enhanced MRI
* Ineligible for other high priority national or institutional study (e.g., protocol CAMP-004)
PATIENT CHARACTERISTICS:
Age:
* Any age
Performance status:
* ECOG 0-1
Life expectancy:
* Not specified
Hematopoietic:
* Not specified
Hepatic:
* Not specified
Renal:
* Creatinine less than 1.5 times normal
Cardiovascular:
* LVEF at least 45% by MUGA
Pulmonary:
* DLCO at least 60% of predicted OR
* Approval by pulmonologist
Other:
* Not pregnant or nursing
* Fertile patients must use effective contraception
* HIV negative
PRIOR CONCURRENT THERAPY:
Biologic therapy:
* Not specified
Chemotherapy:
* See Disease Characteristics
* No other concurrent chemotherapy
Endocrine therapy:
* No concurrent anticancer hormonal therapy
* No concurrent steroids as antiemetics
Radiotherapy:
* See Disease Characteristics
* See Sur…