Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients With Central Nervous Syste… (NCT00007982) | Clinical Trial Compass
CompletedPhase 2
Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients With Central Nervous System Cancer
United States30 participantsStarted 1999-04
Plain-language summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplant may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells.
PURPOSE: This phase II trial is studying how well chemotherapy and peripheral stem cell transplant work in treating patients with central nervous system cancer.
Who can participate
Age range18 Years
SexALL
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DISEASE CHARACTERISTICS:
* Histologically confirmed malignant tumors
* Anaplastic astrocytoma
* Oligodendroglioma
* Germ cell tumor
* Medulloblastoma
* Primary neuroectodermal tumor
* Esthesioneuroblastoma
* CNS lymphoma (primary or systemic disease)
* Multifocal intracranial disease allowed
* No extraneural metastases (except controlled systemic lymphoma)
* Pretreatment considerations based on tumor type
* Anaplastic astrocytoma:
* Recurrent disease
* Any treatment at diagnosis allowed (carmustine dose limited to 480 mg/m2)
* Chemotherapy not required at recurrence
* Oligodendroglioma:
* Disease response (at least minor) to conventional chemotherapy OR
* Recurrent disease
* Esthesioneuroblastoma:
* Attempted complete surgical resection
* Disease progression after radiotherapy
* Response to chemotherapy regimen comprising cyclophosphamide, etoposide, and cisplatin
* CNS lymphoma:
* Disease refractory to methotrexate OR
* Failure after initial treatment with methotrexate OR
* Considered at high risk for disease relapse despite initial response
* Radiographic or pathological confirmation of recurrent disease required
* Not eligible for other high priority national or institutional clinical studies
PATIENT CHARACTERISTICS:
Age:
* 18 and over
Performance status:
* ECOG or Zubrod 0-1
Life expectancy:
* Not specified
Hematopoietic:
* Not specified
Hepatic:
* Not specified
Renal:
* Creatinine less …