Comparison of Two Combination Chemotherapy Regimens in Treating Non-small Cell Lung Cancer (NCT00006004) | Clinical Trial Compass
CompletedPhase 2
Comparison of Two Combination Chemotherapy Regimens in Treating Non-small Cell Lung Cancer
United StatesStarted 2000-08-22
Plain-language summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which combination chemotherapy regimen is more effective for treating non-small cell lung cancer.
PURPOSE: Randomized phase II trial to compare the effectiveness of two combination chemotherapy regimens in treating patients who have non-small cell lung cancer.
Who can participate
Age range18 Years – 120 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically or cytologically confirmed non-small cell lung carcinoma of any of the following subtypes:
* Squamous cell
* Adenocarcinoma
* Large cell anaplastic
* Bronchioalveolar
* Non-small cell carcinoma not otherwise specified
* No small cell anaplastic elements allowed
* Must have:
* Recurrent disease after prior radiotherapy or surgery OR
* Stage IV disease with distant metastases OR
* Stage IIIB disease presenting with pleural or pericardial effusion on CT or chest x-ray or pleural implants documented pathologically or on CT or chest x-ray
* Bidimensionally measurable or evaluable disease
* Brain metastases allowed provided clinically stable after treatment with surgery and/or radiotherapy
PATIENT CHARACTERISTICS:
Age:
* 18 and over
Performance status:
* ECOG 2
Life expectancy:
* Not specified
Hematopoietic:
* Absolute neutrophil count at least 1,500/mm3
* Platelet count at least 100,000/mm3
Hepatic:
* Bilirubin no greater than 1.5 mg/dL
* SGOT no greater than 5 times upper limit of normal
Renal:
* Creatinine no greater than 1.5 mg/dL OR
* Creatinine clearance at least 60 mL/min
Cardiovascular:
* No uncontrolled high blood pressure, unstable angina, or congestive heart failure
* No myocardial infarction within the past 6 months
* No serious ventricular arrhythmias requiring medication
Other:
* Not pregnant or nursing
* Fertile patients must use effective contraception
* No other active malignancies requir…