A Comparison of Two Anti-HIV Treatment Plans

Inclusion Criteria Patients may be eligible if they: * Have proof of MDR virus from a blood test. * Have a viral load above 5,000 copies/ml from the same blood sample showing MDR virus. * Intend to start a new anti-HIV treatment around the time of the study. * Have been on a stable anti-HIV treatment between 14 days prior to the blood test mentioned above and when they are randomly assigned to a treatment. * Are at least 13 years old (consent of parent or guardian required if under 18). * (This protocol has been changed to reflect new criteria.) Exclusion Criteria Patients will not be eligible if they: * Have received a vaccine or had an illness that might affect viral load within 14 days before the blood test showing MDR virus. * Have received IL-2 within 4 months of the above-mentioned blood test or plan to take IL-2 during the study. * Have an opportunistic (AIDS-related) infection requiring treatment. * Are pregnant or breast-feeding. * Are currently participating in CPCRA 057 (PIP study).