RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which regimen of combination chemotherapy is more effective for childhood acute lymphoblastic leukemia. PURPOSE: This randomized phase III trial is comparing different regimens of combination chemotherapy to see how well they work in treating children with acute lymphoblastic leukemia.
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Event-free survival
Timeframe: 4 years
Occurrence of anticipated failures
Timeframe: Up to 7 years
Grade 3 or greater CNS toxicity rates assessed using NCI CTC version 2.0
Timeframe: Up to 7 years