CompletedPhase 2

Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron Disease

40 participantsStarted 1992-10

Plain-language summary

OBJECTIVES: I. Evaluate the effects of androgen suppression with leuprolide and androgen replacement with testosterone enanthate on muscle strength in men with Kennedy's disease or other motor neuron disease.

Who can participate

Age range18 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Men aged 18 and over with motor neuron disease, i.e.: * X-linked spinal and bulbar muscular atrophy (Kennedy's disease) * Confirmed by androgen receptor, exon-1 mutation genotype * Amyotrophic lateral sclerosis * Spinal muscular atrophy Significant muscle weakness on manual muscle testing No prisoners No mental disability

Trial details

NCT IDNCT00004771

SponsorNational Center for Research Resources (NCRR)

Sponsor typeNIH

Study typeINTERVENTIONAL

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