Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers

* INCLUSION CRITERIA: CONTROLS: No psychiatric or severe chronic medical illness at the time of the study, and by history. This includes the absence of substance abuse histories, learning disabilities and all DSM IV disorders. The investigators will evaluate medical histories and medical conditions that are judged not to interfere with the study may be allowed. No use of psychotropic substances in the last 3 months. There is no upper age limit. The lower age limit is 18 years. Controls will all have the capacity to consent. PATIENTS: Schizophrenia, any subtype or schizo-affective disorder according to DSM IV . Bipolar Disorder with Psychotic Features according to DSM IV. Menstrually-Related Mood Disorder. Mild to Moderate Parkinson's Disease (Hoehn and Yahr Stage 1-3). Williams Syndrome (partial or full) with IQ in the normal range. Patients with Multiple Sclerosis. EXCLUSION CRITERIA: CONTROLS AND PATIENTS: Impaired hearing. Pregnancy. Head trauma with loss of consciousness in the last year, or any evidence of functional impairment due to and persisting after head trauma. Patients or healthy volunteers with a known risk from exposure to high magnetic fields (e.g. patients with pace makers) and those who have metallic implants (e.g. braces) in the head region (likely to create artifact on the MRI scans) will be excluded from participating in the fMRI studies. History of any (excepting nicotine-related) DSM5-defined moderate to severe substance use disorder …