Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Dia… (NCT00003273) | Clinical Trial Compass
WithdrawnPhase 2
Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor
United States0Started 1997-11
Plain-language summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of different regimens of combination chemotherapy followed by peripheral stem cell transplantation in treating children who have newly diagnosed brain tumor.
Who can participate
Age range10 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed malignant, newly diagnosed brain tumor
Regimen A:
* Posterior fossa medulloblastoma/primitive neuroectodermal tumor (PNET):
* All stages, under 3 years at diagnosis OR
* High stage (local residual tumor postoperatively and/or neuraxis or extraneural dissemination), 3-10 years at diagnosis
* Supratentorial PNET, pineoblastoma, cerebral neuroblastoma, ependymoblastoma, medulloepithelioma, medullomyoblastoma:
* All stages, under 10 years at diagnosis
* Brainstem PNET:
* All stages, irrespective of extent of resection, under 10 years at diagnosis
* Ependymoma or anaplastic ependymoma:
* All stages, any location (except primary spinal cord ependymoma), under 3 years at diagnosis OR
* Local residual tumor postoperatively and/or neuraxis dissemination, any location, 3-10 years at diagnosis
* Supratentorial ependymoma:
* All stages, irrespective of extent of resection, under 10 years at diagnosis, excluding gross totally resected (confirmed by postoperative MRI) low grade ependymoma not invading the ventricular system
* Metastatic retinoblastoma:
* Previously untreated (except for cryosurgery or laser surgery), under 10 years at presentation of metastatic disease
* Primary atypical teratoid/rhabdoid tumors of the CNS:
* Under 10 years at diagnosis
* Choroid plexus carcinoma:
* Incompletely resected, all sites, under 10 years at diagnosis
Regimen C:
* Anaplastic astrocytoma, glioblastoma multiforme, a…