Central Mechanisms in Speech Motor Control Studied With H215O PET (NCT00001308) | Clinical Trial Compass
TerminatedNot Applicable
Central Mechanisms in Speech Motor Control Studied With H215O PET
United States1,163 participantsStarted 1992-04-28
Plain-language summary
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. Radioactive water H215O in PET scans permits good visualization of areas of the brain related to speech.
Most of the PET scan studies conducted have concentrated on learning about how language is formed and decoded. Few studies have been conducted on speech production. This study aims to use radioactive water (H215O) and Positron Emission Tomography (PET scan) to measure blood flow to different areas of the brain in order to better understand the mechanisms involved in speech motor control.
When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Knowing these facts, researchers can use radioactive chemicals (H215O) and PET scans to observe what areas of the brain are receiving more blood flow.
Researchers will ask patients to perform tasks that will affect speech, voice, and language. At the same time patients will undergo a PET scan. The tasks are designed to help researchers observe the blood flow to brain areas associated with voicebox (laryngeal) functions, movement of muscles in the jaw, tongue, and mouth, and other aspects of motor speech.
Special studies will be conducted to evaluate how certain therapies and tasks can draw out symptoms in illnesses in which speech and language are affected. Results of these tests will be used in other studies to evaluate the neurologic mechanisms of diseases like Tourette's syndrome and parkinson's disease.\<TAB\>
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
* INCLUSION CRITERIA FOR ALL SUBJECTS:
Ages 18 to 85.
Ability to provide informed consent.
Must be a Native English speaker by age 2
SPECIFIC INCLUSION CRITERIA FOR SELECTED GROUPS OF HEALTHY VOLUNTEERS:
Have had training and experience in creative writing
Have had training and experience in vocal or instrumental music
Have had training and experience in visual arts
SPECIFIC INCLUSION CRITERIA FOR POST-STROKE APHASIA SUBJECTS:
Had sensorimotor and language deficits following ischemic infarcts.
Had stroke at least two weeks ago.
SPECIFIC INCLUSION CRITERIA FOR TRAUMATIC BRAIN INJURY SUBJECTS:
Diagnosis of TBI
At least one month post-injury
SPECIFIC INCLUSION CRITERIA FOR STUTTERING SUBJECTS:
History of developmental stuttering with symptoms of dysfluency presenting before the age of 13
If recovered, history documented by school or medical records.
SPECIFIC INCLUSION CRITERIA FOR EPILEPSY SUBJECTS:
Ages 18 to 55 years.
Failure of seizures to respond to adequate therapy with at least two standard antiepileptic drugs.
Willingness to be considered for surgery
Fluency in English. Non-native speakers may be included if their fluency is equivalent to that of a native speaker.
Must have localization-related epilepsy
Must be currently enrolled in Protocol 08-N-0161 to participate in this study
EXCLUSION CRITERIA FOR ALL SUBJECTS:
Past or present major medical or psychiatric illnesses (DSM-IV criteria) except Post Traumatic Stress Disorder (PTSD) in TBI subjects…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Trial details
NCT IDNCT00001308
SponsorNational Institute on Deafness and Other Communication Disorders (NIDCD)