RecruitingNot Applicable

Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV

United States2,419 participantsStarted 1993-03-09

Plain-language summary

We are studying virologic and/or immunologic parameters of HIV infection and other infectious or non-infectious immune deficiency diseases in order to better understand the pathogenesis of HIV. Because of the lack of an adequate animal model it is generally necessary to utilize human peripheral blood cells for studying aspects of either in vivo or in vitro HIV infection. We wish to be able to continue to elucidate many pathogenic aspects of HIV infection in relation to other infectious or non-infectious immune regulation and dysregulation using human peripheral blood mononuclear cells as a model.

Who can participate

Age range18 Years – 120 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

* INCLUSION CRITERIA: * 18 years of age or older. * Adequate venous access. * Have a blood pressure less than or equal to 180/100: pulse rate 50-100, unless a lower pulse rate is considered normal for the volunteer. * Have adequate blood counts (volunteers living with HIV: hemoglobin greater than or equal to 9.0 g/dL, platelets greater than or equal to 50,000; volunteers living without HIV: hemoglobin greater than or equal to 9.0 g/dL, platelets greater than or equal to 50,000 * Be willing and able to provide written informed consent on screening, comply with study requirements and procedures, and comply with clinic policies * Willingness to allow blood samples to be used for future studies of HIV infection/pathogenesis, and undergo hepatitis screening EXCLUSION CRITERIA: * Pregnant and/or breastfeeding females. * Active substance abuse or history of prior substance abuse that may interfere with protocol compliance or compromise volunteer safety.

What they're measuring

The purpose of this protocol is to provide a mechanism to obtain blood products and other biologic samples that will be used by NIH Intramural Investigators in studies of HIV and other infectious or immune deficiency diseases

Timeframe: Throughout

Trial details

NCT IDNCT00001281

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)

Sponsor typeNIH

Study typeOBSERVATIONAL

Contact for this trial

Catherine A Seamon, R.N.

(301) 402-3481 cseamon@cc.nih.gov