Natural History of Thyroid Function Disorders (NCT00001159) | Clinical Trial Compass
RecruitingNot Applicable
Natural History of Thyroid Function Disorders
United States2,500 participantsStarted 1977-02-01
Plain-language summary
Participants in this study will be patients diagnosed with or suspected to have a thyroid function disorder. These conditions may include: hypothyroidism, hyperthyroidism, thyroid hormone resistance, Graves' Dermopathy, and thyroid-stimulating hormone (TSH) secreting pituitary adenomas.
The main purpose of this study is to further understand the natural history, clinical presentation, and genetics of thyroid function disorders. Many of the tests performed are in the context of standard medical care that is offered to all patients with thyroid function disorders. In addition, blood and tissue samples may be taken for research and genetic studies....
Who can participate
Age range6 Months – 98 Years
SexALL
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Inclusion criteria
✓. Patients with known or suspected thyroid abnormalities (e.g. hypothyroidism, hyperthyroidism, extreme iodine deficiency, and inherited forms of hypothyroidism resulting from abnormalities in the expression of genes coding for the TSH- beta subunit, Pax-8, TTF-2, Pit-I, Tg, PDS, and NIS.
✓. Patients with thyroid function test (TFT) abnormalities due to:
Exclusion criteria
✕. Stated willingness to comply with all study procedures and availability for the duration of the study.
✕. Male or female, aged 6 months+.
✕. Graves' disease (GD) thought to result from thyroid-stimulating immunoglobulins (TSIg's), a subclass of which also stimulate eye muscle and fatty tissue producing exophthalmos (Graves' ophthalmopathy), as well as the skin in the pretibial area causing pretibial myxedema (Graves' dermopathy);
✕. Subacute thyroiditis (SAT), a painful inflammation thought to result from viral infection with Coxsackie, as well as other viruses;
✕. Silent thyroiditis, a painless inflammation thought to result from autoimmune attack of thyrocytes by antimicrosomal antibodies directed against thyroid peroxidase (TPO), as well as antithyroglobulin(anti-Tg) antibodies;
What they're measuring
1
evaluation of thyroid disorders
Timeframe: ongoing
Trial details
NCT IDNCT00001159
SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
✕. Single or multiple hyperfunctioning thyroid nodules of unknown etiology, probably resulting from the activation of certain thyroid oncogenes and/or growth factors, such as the thyrotropin (TSH) receptor (TSHR) and the a-subunit of the G protein (Ga);
✕. Iodide-induced hyperthyroidism of unknown etiology;
✕. Surreptitious administration of thyroid hormone (TH), usually present in patients with underlying psychiatric disease or occasionally related to patients with obesity and other eating disorders