CompletedPhase 1

Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)

United States36 participants

Plain-language summary

The purpose of this study is to see what dose of the drug cidofovir is safe to treat laryngeal papillomatosis (warts in the throat which occur over and over) in children. Laryngeal papillomatosis is caused by infection with a virus called human papillomavirus (HPV). At present, there is no approved drug to treat this infection. However, cidofovir is a drug effective against several viruses. Cidofovir may be able to attack the HPV virus. This study tests the safety of giving this drug to children.

Who can participate

Age range2 Years – 17 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Your child may be eligible for this study if he/she: * Has active laryngeal papillomatosis (warts in the throat) that requires 8 or more surgeries per year. * Developed this infection before the age of 16. * Is between the ages of 2 and 17 years with consent of parent or guardian. Exclusion Criteria: Your child will not be eligible for this study if he/she: * Has a history of a prior malignancy (cancer), kidney disease, or immune system deficiency. * Is HIV-positive. * Is allergic to probenecid. * Has received radiation therapy to the throat area or has received certain medications. * Is pregnant or breast-feeding.

Trial details

NCT IDNCT00001126

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)

Sponsor typeNIH

Study typeINTERVENTIONAL

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