A Collaborative Double-Blind Placebo-Controlled Trial of Intravenous Ribavirin As a Treatment for… (NCT00001123) | Clinical Trial Compass
CompletedNot Applicable
A Collaborative Double-Blind Placebo-Controlled Trial of Intravenous Ribavirin As a Treatment for Presumed Hantavirus Pulmonary Syndrome
United States130 participants
Plain-language summary
The purpose is to test the safety and effectiveness of intravenous ribavirin therapy in persons with suspected and subsequently proven hantavirus infection. The hantavirus is spread through the air into the lungs when dry rodent feces are moved or disturbed. It is characterized by fever and bleeding.
Who can participate
Age range
12 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
You may be eligible for this study if you:
* Are 12 years of age or older.
* Are not pregnant.
* Agree to practice sexual abstinence or use accepted barrier methods of birth control/contraception.
* Are not breast-feeding.
* Have a positive blood test for hantavirus.
* Have symptoms suggestive of hantavirus illness.
Exclusion Criteria:
You will not be eligible for this study if you:
* Have severe low blood count (anemia).
* Have a diagnosis of other respiratory viruses (influenza, RSV, etc.).
* Have group A Streptococcus with symptoms of streptococcal pharyngitis, a positive culture from a normally sterile site, or symptoms of bacterial pneumonia.
* Are HIV positive.
* Have cancer.
* Have had any period of irregular heartbeat.
* Have had chemotherapy or other drugs that suppress the immune system within 30 days.
* Have taken by mouth or injection any antiviral drug (other than acyclovir, famciclovir, amantadine or rimantadine.)
* Have taken by mouth or injection corticosteroids equivalent to approximately 0.5 mg/kg prednisone.
* Have taken any experimental drug within 30 days prior to enrollment.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Trial details
NCT IDNCT00001123
SponsorNational Institute of Allergy and Infectious Diseases (NIAID)