Study and Treatment of Post Lyme Disease (STOP-LD)

Inclusion Criteria: You may be eligible for this study if you: * Are between 18 and 65 years of age. * Are a resident of Long Island or greater NY metropolitan area. * Are fluent in English. * Have a history of Lyme Disease. * Have completed antibiotic treatment for Lyme Disease 6 or more months before starting the study. * Have severe fatigue. * Are not pregnant or planning to be pregnant. Exclusion Criteria: You will not be eligible for this study if you: * Have or have had major medical, neurologic, or psychiatric disorder. * Have had prior chronic pain, fatigue, or recurrent severe headaches before the onset of Lyme Disease. * Have had Fibromyalgia Syndrome. * Have a history of sleep apnea, narcolepsy, or other serious sleep disorder. * Have a learning disability. * Have had head trauma requiring hospitalization. * Have symptomatic gallbladder disease. * Are anemic. * Abuse alcohol or illicit drugs. * Have been treated with another antimicrobial agent for Lyme Disease within 6 months of study. * Need to be receiving systemic steroid therapy during drug administration and follow-up. * Have used benzodiazepines within 1 month of study entry. * Are allergic to Beta lactams (a class of antibiotics).