Randomized, Double-Blind, Placebo-Controlled Trial of Nimodipine for the Neurological Manifestations of HIV-1

Inclusion Criteria Concurrent Medication: Allowed: * Alternative or additional antiretroviral agents if on a stable dose for 8 weeks prior to study entry. * Isoniazid. * Anticonvulsants. * Benzodiazepines and antidepressants (provided dose is stable prior to study entry). * Symptomatic therapies (e.g., analgesics, antihistamines, antiemetics, and antidiarrheal agents). * Maintenance therapy with clarithromycin, azithromycin, amikacin, ethambutol, clofazimine, ciprofloxacin, and rifampin for disseminated Mycobacterium avium infection. * Maintenance therapy for opportunistic infections (e.g., PCP, MAI, CMV). Patients must have: * Documented HIV infection. * HIV-Associated Motor / Cognitive Complex. * Acceptable neurological and neuropsychological impairment scores. * Estimated premorbid IQ of 70 or greater, consistent with completion of the sixth grade or ability to read at the sixth grade level. Current ability to read and comprehend a newspaper or history of such ability will satisfy this criterion for patients whose formal education stopped before the sixth grade. For patients who are illiterate, ability to make change from a dollar for a combined purchase of two items or the history of such ability will satisfy this criterion. In the absence of a functional definition, an age-correlated scaled score of \> 5 on the Vocabulary Subtest of the WAIS-R or WISC-R may be used to establish IQ. * Ability to provide written informed consent. Prior Medication: Required: * AZT f…