CompletedPhase 2

A Laboratory Model for Heroin Abuse Medications - 8

United States8 participantsStarted 1995-08

Plain-language summary

The purpose of this study is to evaluate the effects of treatment medications (methadone, buprenorphine, LAAM, naltrexone, naltrexone microcapsules, and methoclocinnamox) on I.V. and smoked heroin self-administration."

Who can participate

Age range18 Years – 45 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. DSM IV criteria for opioid dependence
✓. No major mood, psychotic, or anxiety disorder
✓. Physically healthy
✓. Able to perform study procedures
✓. 21-45 years of age
✓. Current use of i.v. heroin in amounts/frequencies
✓. Not seeking treatment for opioid dependence

Exclusion criteria

✕. DSM IV criteria for dependence on drugs other
✕. Participants requesting treatment
✕. Participants on parole or probation
✕. Pregnancy or lactation
✕. Birth, miscarriage or abortion with 6 months
✕. Recent history of or current significant violent behavior
✕. Current major Axis I psychopathology, other than heroin dependence ( e.g., mood disorder with functional impairment or suicide risk, schizophrenia), which might interfere with ability to participate in the study
✕. Hepatitis with SGOT or SGPT \> 3 times normal

What they're measuring

Amount drug self-administered

Timeframe: 90 minutes

Trial details

NCT IDNCT00000273

SponsorNew York State Psychiatric Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2005-11

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