Severe Sepsis and Septic Shock

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Severe Sepsis and Septic Shock trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 21 trials

RecruitingNot Applicable

NCT03244293

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its u…

China20 participantsStarted 2014-01-01

Treatment: no intervention

RecruitingNot Applicable

NCT04203979

Sepsis: From Syndrome to Personalized Care

This is a prospective, observational study designed to examine the performance of biomarkers, molecular biological methods and other analysis in blood from pati…

Norway1,950 participantsStarted 2020-01-06

RecruitingNot Applicable

NCT06809868

Role of Transposable Elements in Septic Immune Aging

The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answ…

United States116 participantsStarted 2025-02-14

Treatment: RNA and DNA Sequencing

RecruitingNot Applicable

NCT06217939

Early Intravenous Hydrocortisone in Sepsis

The goal of this clinical trial is to compare two timings of steroid treatment in patients with severe infection who develop low blood pressure. The main quest…

Thailand230 participantsStarted 2024-06-25

Treatment: Early hydrocortisone, Normal saline placebo

RecruitingNot Applicable

NCT07312474

Epidemiological, Clinical and Biological Characteristics of Human Anaplasmosis Cases in Alsace

Anaplasmosis is a bacterial infection caused by the intracellular bacterium Anaplasma phagocytophilum and transmitted by ticks. This bacterium is present in app…

France100 participantsStarted 2024-10-02

RecruitingNot Applicable

NCT07286643

Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis

* Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without system…

India140 participantsStarted 2026-01-01

Treatment: POCUS, Fixed Resuscitation Strategy based on Target MAP

All recent trials (100 shown)

Not Yet RecruitingPhase 3

NCT07569536

Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock

Septic shock is one of the most frequent reasons for admission to intensive care units and remains associated with a high mortality rate of approximatively 40%…

France360 participantsStarted 2026-09-01

Treatment: Dexmedetomidine 100 µg/mL, intravenous solution, Stardard care

CompletedPhase 4

NCT03068741

Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)

Sepsis occurs when a serious infection - most commonly infection of the lungs, urinary system, or blood - leads to acute organ failure. It is a common, expensiv…

Canada2,061 participantsStarted 2020-03-23

Treatment: Comparison 1: Prehospital Ceftriaxone, Comparison 1: Placebo

Severe Sepsis and Septic Shock

Trial phase breakdown

Trial status

Actively recruiting — 21 trials

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

Sepsis: From Syndrome to Personalized Care

Role of Transposable Elements in Septic Immune Aging

Early Intravenous Hydrocortisone in Sepsis

Epidemiological, Clinical and Biological Characteristics of Human Anaplasmosis Cases in Alsace

Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis

All recent trials (100 shown)

Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock

Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)

Trial phase breakdown

Trial status

Actively recruiting — 21 trials

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

Sepsis: From Syndrome to Personalized Care

Role of Transposable Elements in Septic Immune Aging

Early Intravenous Hydrocortisone in Sepsis

Epidemiological, Clinical and Biological Characteristics of Human Anaplasmosis Cases in Alsace

Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis

All recent trials (100 shown)

Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock

Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study

I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)

COrporeal Compression at the ONset of Severe Sepsis and Septic Shock

REAnimation Low Immune Status Markers

Pediatric Immune Response to Infectious Shock

Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock

Predictive Mini-bolus Fluid Responsiveness in Pediatric Septic Shock

Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis

GM-CSF to Decrease ICU Acquired Infections

L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury

Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?

LIPIDS-P Trial Phase I/II Trial

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia

Vasopressin Use in Septic Shock From Türkiye

Citrulline and Arginase Activity in Severe Sepsis and Septic Shock

Risk Factors Identification of Sepsis and Septic Shock After Major Abdominal Surgery Based on Artificial Intelligence

A Multicenter Prospective Observational Study to Derive and Verify the Performance of a Host-response Based Diagnostic T…