Severe Pre-Eclampsia

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Severe Pre-Eclampsia trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 11 trials

RecruitingPhase 2

NCT02989025

Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia

The purpose of this study is to learn if giving 17-hydroxyprogesterone caproate (17 OHPC) to mothers with preeclampsia diagnosed before 34 weeks gestation impro…

United States60 participantsStarted 2017-05-22

Treatment: 17 OHPC

RecruitingPhase 2

NCT06333652

Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders

The researchers are testing a medication named ravulizumab for the treatment of severe preeclampsia and Hemolysis, Elevated Liver enzymes, Low Platelets (HELLP)…

United States14 participantsStarted 2026-09-01

Treatment: Ravulizumab

RecruitingNot Applicable

NCT07263490

PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)

The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant af…

Denmark462 participantsStarted 2024-10-21

RecruitingNot Applicable

NCT07443345

Incidence of Postoperative Diaphragmatic Dysfunction in Pregnant Women With Preeclampsia

Preeclampsia with severe features remains a leading contributor to maternal morbidity and mortality, particularly in low- and middle-income countries. It is def…

Egypt52 participantsStarted 2026-03-09

RecruitingPhase 2

NCT07098975

Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)

In pregnancies with placental insufficiency, the only available treatment is close monitoring to determine the point at which the risks of preterm birth for the…

Spain154 participantsStarted 2026-01-14

Treatment: Pravastatin 40 mg, Placebo

RecruitingPhase 4

NCT07361679

LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention

Preeclampsia is a major cause of maternal and perinatal morbidity and mortality worldwide. Low-dose aspirin started in the first trimester reduces the risk of p…

Greece100 participantsStarted 2023-01-18

Treatment: Aspirin, Tinzaparin

All recent trials (100 shown)

CompletedNot Applicable

NCT07572656

Comparison of Intravenous Labetalol and Intravenous Hydralazine in Severe Preeclampsia

Due to limited data regarding preeclampsia from the local population, the debate is still ongoing in the study setting. Hence, the current study was planned to…

Pakistan132 participantsStarted 2024-05-01

Treatment: Labetalol, Hydralazine

Not Yet RecruitingNot Applicable

NCT07547046

Factors Associated With Blood Pressure Control Failure to Intravenous Labetalol in Severe Preeclampsia

Severe preeclampsia is a serious pregnancy complication that can lead to severe maternal and fetal outcomes, particularly when blood pressure is not adequately…

France350 participantsStarted 2026-04-01

Severe Pre-Eclampsia

Trial phase breakdown

Trial status

Actively recruiting — 11 trials

Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia

Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders

PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)

Incidence of Postoperative Diaphragmatic Dysfunction in Pregnant Women With Preeclampsia

Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)

LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention

All recent trials (100 shown)

Comparison of Intravenous Labetalol and Intravenous Hydralazine in Severe Preeclampsia

Factors Associated With Blood Pressure Control Failure to Intravenous Labetalol in Severe Preeclampsia

Trial phase breakdown

Trial status

Actively recruiting — 11 trials

Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia

Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders

PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)

Incidence of Postoperative Diaphragmatic Dysfunction in Pregnant Women With Preeclampsia

Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)

LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention

All recent trials (100 shown)

Comparison of Intravenous Labetalol and Intravenous Hydralazine in Severe Preeclampsia

Factors Associated With Blood Pressure Control Failure to Intravenous Labetalol in Severe Preeclampsia

Biomarkers in Management of Post Partum Preeclampsia

Finger Plethysmography to Predict Fluid Responsiveness in Healthy Pregnancy and Severe Preeclampsia

Optimizing Preeclampsia Postpartum With Point-of-care Ultrasound

Pharmacokinetic Study to Evaluate Safety and Tolerability of EG-101 in Healthy Female Volunteers as a Safety Lead-In for…

Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial

Levetiracetam Compared to Magnesium Sulfate for Prevention of Eclamptic Seizure

Preeclampsia Educational Program Study (PrEPS)

Diastolic Dysfunction 2025

Postpartum Video Education in High Risk Populations

The Association Between Different Markers With Development of Maternal and Neonatal Complications in Women With Severe P…

Assessment of Maternal and Fetal Serum Biomarkers in Women With Pre-eclampsia

Metformin and Esomeprazole in Preterm Pre-eclampsia

Optic Nerve Sheath Diameter in Pre-Eclamptic Parturient Receiving Magnesium Sulfate Combined With Dexmedetomidine

Low Doses of Aspirin in the Prevention of Preeclampsia

A Feasibility Study to Evaluate the Safety of the KNP-1000 Apheresis System in Severe Preeclampsia

Serum Magnesium Concentration in Magnesium Sulfate Therapy for Severe Preeclampsia

Intravenous Labetalol Versus Hydralazine in Preeclampsia

Patient Satisfaction With Abbreviated Postpartum Magnesium Sulfate for Severe Preeclampsia