Sepsis and Septic Shock

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Sepsis and Septic Shock trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 34 trials

RecruitingNot Applicable

NCT05928767

Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted…

The aim of the study is to demonstrate that "frail" patients, defined as having a CFS score greater than or equal to 5, and "severely" frail patients, defined a…

France200 participantsStarted 2023-08-21

RecruitingNot Applicable

NCT07300306

Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey

The goal of this observational study is to validate the effectiveness of the new SOFA-2 score in predicting mortality and to determine the current frequency of…

Turkey (Türkiye)2,500 participantsStarted 2026-05-04

RecruitingNot Applicable

NCT07179276

Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock

Sepsis is a dysregulated host response to infection that leads to life-threatening organ dysfunction and represents a major healthcare problem. Septic shock is…

France750 participantsStarted 2026-03-29

Treatment: CO2gap-guided resuscitation strategy

RecruitingNot Applicable

NCT07068022

Organ Dysfunction Score for Obstetric Patients

The goal of this observational study is to develop and evaluate an organ dysfunction score adapted to pregnancy and early puerperium (SOFA-OBS) that also incorp…

Argentina130 participantsStarted 2025-10-06

Treatment: Organ dysfunction score adjusted to obstetric patients (SOFA-OBS)

RecruitingNot Applicable

NCT07550400

Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients

Fluid replacement is considered the cornerstone of hemodynamic management in critically ill patients especially in patients with septic shock. However, only abo…

Egypt40 participantsStarted 2026-05-03

Treatment: carotid artery duplex, Left ventricular end diastolic area

RecruitingNot Applicable

NCT03244293

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its u…

China20 participantsStarted 2014-01-01

Treatment: no intervention

All recent trials (100 shown)

CompletedNot Applicable

NCT03292120

Venous to Arterial Carbon Dioxide Difference (P₍ᵥ-ₐ₎CO₂): Predictor of Septic Patient Prognosis Depending on the ScvO₂

the investigators will include 120 patients with a diagnosis of septic shock in accordance with the definition given by the 2001 expert consensus. Two groups of…

France124 participantsStarted 2016-06

Treatment: measure of the SOFA score

Not Yet RecruitingPhase 3

NCT07569536

Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock

Septic shock is one of the most frequent reasons for admission to intensive care units and remains associated with a high mortality rate of approximatively 40%…

France360 participantsStarted 2026-09-01

Treatment: Dexmedetomidine 100 µg/mL, intravenous solution, Stardard care

Sepsis and Septic Shock

Trial phase breakdown

Trial status

Actively recruiting — 34 trials

Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted…

Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey

Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock

Organ Dysfunction Score for Obstetric Patients

Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

All recent trials (100 shown)

Venous to Arterial Carbon Dioxide Difference (P₍ᵥ-ₐ₎CO₂): Predictor of Septic Patient Prognosis Depending on the ScvO₂

Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock

Trial phase breakdown

Trial status

Actively recruiting — 34 trials

Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted…

Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey

Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock

Organ Dysfunction Score for Obstetric Patients

Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

All recent trials (100 shown)

Venous to Arterial Carbon Dioxide Difference (P₍ᵥ-ₐ₎CO₂): Predictor of Septic Patient Prognosis Depending on the ScvO₂

Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock

Use of Oxiris Filter in Septic Shock Patients Requiring Renal Replacement Therapy: A Retrospective Cohort Study

Protocolised Early De-Resuscitation in Septic Shock (REDUCE)

Comparison of Angiotensin II to Standard Dose Vasopressors on Change in Arterial Elastance

Impact of Systematic Point-of-Care Ultrasound Implementation on Clinical Outcomes and Survival in Septic Shock: A Retros…

Plasma Host-Microbe Proteomics to Predict Complications in High-risk Febrile Neutropenia

Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)

Clinical Efficacy of Megadose Vitamin C in Sepsis

Blood Purification for the Treatment of Pathogen Associated Shock

Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock

Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study

Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock

Multimodal Vasopressor Strategy in Septic Shock

Assessing the Efficacy of Dapagliflozin as a Vasculoprotective Treatment in Septic Shock Patients With Microcirculatory…

Prognostic Interest of Vasorin in Septic Shock

Time to Lose the Weight? Comparison of Weight-based and Non-weight-based Vasopressors for Septic Shock

Validation of the Use of the Arteriovenous Tension Difference in CO2 Under Hyperbaric Conditions

Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial