Right Heart Failure

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Right Heart Failure trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 38 trials

RecruitingPhase 2

NCT06053580

Repurposing Valsartan May Protect Against Pulmonary Hypertension

This is a Phase 2, single-center, randomized placebo controlled trial of valsartan (an angiotensin receptor blocker) in adults with pulmonary arterial hypertens…

United States60 participantsStarted 2024-02-28

Treatment: Valsartan 40 mg, Placebo

RecruitingNot Applicable

NCT07217392

Left Bundle Branch Area Pacing (LBBAP) PMCF Study

The objective of this study is to evaluate the safety and effectiveness of LBBA pacing/sensing in patients implanted with the Tendril STS 2088TC or UltiPace LPA…

Brazil, France +2 more200 participantsStarted 2025-07-24

Treatment: LBBAP lead

RecruitingNot Applicable

NCT07224906

Observational Study of Patients Undergoing Diagnostic Right Heart Catheterization

The objective of this observational pilot study is to collect HemoCept device data from subjects undergoing diagnostic right heart catheterization (RHC) procedu…

United States50 participantsStarted 2025-12-01

RecruitingNot Applicable

NCT03838445

Reducing Right Ventricular Failure in Pulmonary Arterial Hypertension (RELIEVE-PAH)

The objectives of the RELIEVE-PAH study are to obtain first-in-human experience with the study device in patients with severe pulmonary arterial hypertension, i…

United States, Canada, Mexico20 participantsStarted 2020-02-14

Treatment: V-Wave Interatrial Shunt

RecruitingNot Applicable

NCT03836482

Feasibility of the SCD in Cardiorenal Syndrome Patients Awaiting LVAD

Cardiovascular disease is the leading cause of mortality in the US, accounting for 45% of all deaths. Chronic Heart Failure (CHF) is now understood to be a mult…

United States20 participantsStarted 2025-10-02

Treatment: Selective Cytopheretic Device

RecruitingPhase 1

NCT06770023

Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pul…

The purpose of this study is to determine if transseptal extra-corporeal membrane oxygenation (ECMO) can bridge pulmonary hypertension- right heart failure (PH-…

United States4 participantsStarted 2026-06-11

Treatment: Protek Solo Transseptal Cannula

All recent trials (100 shown)

CompletedPhase 4

NCT03344159

Spironolactone Therapy in Chronic Stable Right HF Trial

The purpose of this study is to evaluate the safety, tolerability and mechanistic effects of spironolactone, an aldosterone receptor antagonist, on sympathetic…

Canada15 participantsStarted 2018-04-01

Treatment: Spironolactone, Placebo

SuspendedNot Applicable

NCT04909008

Exercise Training to Improve Cardiopulmonary Hemodynamics in Heart Failure Patients

This research study is being done to find out if exercise therapy can help improve the heart function, overall health, and quality of life of patients with pulm…

United States40 participantsStarted 2024-01-01

Treatment: Exercise Training

Right Heart Failure

Trial phase breakdown

Trial status

Actively recruiting — 38 trials

Repurposing Valsartan May Protect Against Pulmonary Hypertension

Left Bundle Branch Area Pacing (LBBAP) PMCF Study

Observational Study of Patients Undergoing Diagnostic Right Heart Catheterization

Reducing Right Ventricular Failure in Pulmonary Arterial Hypertension (RELIEVE-PAH)

Feasibility of the SCD in Cardiorenal Syndrome Patients Awaiting LVAD

Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pul…

All recent trials (100 shown)

Spironolactone Therapy in Chronic Stable Right HF Trial

Exercise Training to Improve Cardiopulmonary Hemodynamics in Heart Failure Patients

Trial phase breakdown

Trial status

Actively recruiting — 38 trials

Repurposing Valsartan May Protect Against Pulmonary Hypertension

Left Bundle Branch Area Pacing (LBBAP) PMCF Study

Observational Study of Patients Undergoing Diagnostic Right Heart Catheterization

Reducing Right Ventricular Failure in Pulmonary Arterial Hypertension (RELIEVE-PAH)

Feasibility of the SCD in Cardiorenal Syndrome Patients Awaiting LVAD

Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pul…

All recent trials (100 shown)

Spironolactone Therapy in Chronic Stable Right HF Trial

Exercise Training to Improve Cardiopulmonary Hemodynamics in Heart Failure Patients

A Study of Surgical Interventions in Fistulizing Conditions

Bachmann Bundle Pacing for Prevention of New-Onset Atrial Fibrillation in Patients With Heart Failure

Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients

RAFT-TAVR PACE: LBBAP vs. RVP Post-TAVR in Patients Requiring PPI

Evolution of Hypoxic Burden and Sympathetic/Parasympathetic Balance in Patients With Pulmonary Hypertension

Effect of PEEP on Cardiac Function

The Nanowear Wearable System SimpleSense Validation Trial for Cardiac Output

Accelerated LBBP for Patients With RHF and Severe TR

A Multi-site, Pre-clinical, Prospective Data Collection Study in Patients Undergoing a Right Heart Catheterization

Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respiratory Distre…

CardioNETPOL National Registry of Carcinoid Heart Disease

Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects With Reduced Ejection Fraction

Adherence of Diuretics in Pulmonary Hypertension

Evaluation of the Sensitivity, Specificity, and Utility of the Reveal® TP (Syphilis) Antibody POCT

Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE

Cardiac Assessment by PV Loop in IPAH and Scleroderma PAH

Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block)

Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients