Polycystic Kidney Diseases

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Polycystic Kidney Diseases trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 38 trials

RecruitingNot Applicable

NCT02497521

The German ADPKD Tolvaptan Treatment Registry

The German ADPKD Tolvaptan Treatment Registry is a prospective, observational, multicentric study of patients suffering from ADPKD that are considered for tolva…

Germany2,000 participantsStarted 2015-11

RecruitingNot Applicable

NCT02936791

Early PKD Observational Cohort Study

This observational study will collect blood and urine and clinical information from individuals with early-stages of polycystic kidney disease (PKD), their unaf…

United States250 participantsStarted 2016-04

RecruitingPhase 2

NCT07161037

Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)

The purpose of the study is to evaluate the effect of VX-407 on height-adjusted total kidney volume (htTKV), safety, tolerability, and pharmacokinetics (PK) of…

United States24 participantsStarted 2025-11-19

Treatment: VX-407

RecruitingNot Applicable

NCT06147414

Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders

Cell-free fetal DNA (cffDNA) is present in the maternal blood from the early first trimester of gestation and makes up 5%-20% of the total circulating cell-free…

France550 participantsStarted 2024-10-23

Treatment: Blood sample

RecruitingNot Applicable

NCT07535385

RADIOLOGICAL AND CLINICAL EVALUATION OF RENAL EMBOLIZATION USING EVOH IN DIALYSIS PATIENTS WITH AUTOSOMAL DOMINANT POLYC…

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited cystic disorder characterised by the progressive degeneration of the renal parenchyma into…

Italy30 participantsStarted 2020-08-17

RecruitingPhase 3

NCT04939935

Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)

This study will investigate if a medication (metformin) widely used in the treatment of diabetes could be re-purposed for the treatment of patients with a diagn…

Australia1,174 participantsStarted 2022-11-29

Treatment: Metformin XR, Control

All recent trials (100 shown)

Active — Not RecruitingNot Applicable

NCT05460169

Renal Denervation in ADPKD- RDN-ADPKD Study

RDN-ADPKD is a prospective, randomized (1:1, central randomization), single-center, hypothesis-generating, feasibility study. The purpose of the RDN-ADPKD study…

Germany44 participantsStarted 2022-06-14

Treatment: Renal denervation

Not Yet RecruitingPhase 1

NCT07565441

Drug-Drug Interactions of JMKX003142 in Healthy Participants

This is a single-center, non-randomized, open-label, self-controlled, Phase I clinical trial to evaluate the drug-drug interactions (DDI) of JMKX003142 tablets…

Location not specified112 participantsStarted 2026-05-11

Treatment: JMKX003142 tablets, Fluconazole Capsules

Polycystic Kidney Diseases

Trial phase breakdown

Trial status

Actively recruiting — 38 trials

The German ADPKD Tolvaptan Treatment Registry

Early PKD Observational Cohort Study

Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)

Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders

RADIOLOGICAL AND CLINICAL EVALUATION OF RENAL EMBOLIZATION USING EVOH IN DIALYSIS PATIENTS WITH AUTOSOMAL DOMINANT POLYC…

Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)

All recent trials (100 shown)

Renal Denervation in ADPKD- RDN-ADPKD Study

Drug-Drug Interactions of JMKX003142 in Healthy Participants

Trial phase breakdown

Trial status

Actively recruiting — 38 trials

The German ADPKD Tolvaptan Treatment Registry

Early PKD Observational Cohort Study

Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)

Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders

RADIOLOGICAL AND CLINICAL EVALUATION OF RENAL EMBOLIZATION USING EVOH IN DIALYSIS PATIENTS WITH AUTOSOMAL DOMINANT POLYC…

Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)

All recent trials (100 shown)

Renal Denervation in ADPKD- RDN-ADPKD Study

Drug-Drug Interactions of JMKX003142 in Healthy Participants

Bempedoic Acid Therapy for Polycystic Kidney Disease

Feasibility of Study of Empagliflozin in Patients With Autosomal Dominant Polycystic Kidney Disease

Renal Oxygen Consumption, Insulin Sensitivity, and Daily Caloric Restriction in ADPKD

Observational Study in Patients With Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease 1 (PKD1) Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease

A Study to Evaluate Homocysteine Metabolism and Endothelial Function in ADPKD

Lanreotide In Polycystic Kidney Disease Study

Effects of VX-407 on the Pharmacokinetics of Oral Contraceptives in Healthy Participants

A Phase 1 Study Evaluating Safety, Tolerability, and Pharmacokinetics of VX-407 in Healthy Participants

A Possible Founding PKD2 Mutation Associated With Variable Phenotypes of ADPKD in Bergamo Province

A Study to Investigate the Effects of JMKX003142 on QTc Interval in Healthy Adults

Mass Balance and Absolute Bioavailability Study of JMKX003142 In Healthy Volunteers

Urine Albumin/Creatinine Ratio and Renal Function Differences in Phenotypes of Polycystic Ovary Syndrome.

Safety of RotigotiNe in Patients With Autosomal Dominant Polycystic Kidney Disease

Di-PKD: A Pilot Trial of Dietary Intervention in Patients With Autosomal Dominant Polycystic Kidney Disease

Probenecid (PB) to Treat Hereditary Nephrogenic Diabetes Insipidus (NDI), ADPKD Treated With Tolvaptan, and Severely Pol…

Autosomal Dominant Polycystic Kidney Disease Somatic Mutation Biorepository

Robotic vs Open Nephrectomy for ADPKD