Palmar-Plantar Erythrodysesthesia Syndrome

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Palmar-Plantar Erythrodysesthesia Syndrome trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 6 trials

RecruitingPhase 2

NCT07560566

SHIELD: Sorafenib Hand-foot Syndrome Inhibition With Pre-Emptive Local Delivery of Topical Indomethacin

SHIELD is a single-center, open-label, single-arm prospective study designed to evaluate whether pre-emptive topical indomethacin can reduce sorafenib-associate…

Taiwan39 participantsStarted 2025-12-09

Treatment: Topical Indomethacin

RecruitingNot Applicable

NCT07114627

Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients

In this study, the drug capecitabine is investigated. Capecitabine is commonly used to treat breast, colon, and stomach cancers. Capecitabine is taken in tablet…

Netherlands66 participantsStarted 2025-02-18

Treatment: Blood sampling for pharmacokinetics

RecruitingNot Applicable

NCT06602167

Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot S…

This study hypothesizes that electroacupuncture combined with self-administered acupressure plus doctor-prescribed treatment is effective in preventing Hand-Foo…

China220 participantsStarted 2024-10-08

Treatment: True electroacupuncture + True self-administered acupressure, Doctor-prescribed treatment

RecruitingNot Applicable

NCT06639178

Effectiveness of an N-acetylcysteine and Urea-based Cream in Prevention of Capecitabine-induced HAND-foot Syndrome in Br…

Breast cancer (BC) is the most frequent tumour in women. To date, among the available treatments, the use of Capecitabine, an oral prodrug of fluorouracil, has…

Italy25 participantsStarted 2024-08-01

Treatment: DECLARAN cream

RecruitingNot Applicable

NCT06441513

The Preventive Effect of Chemotherapy-induced Hand-foot Syndrome

this study will use traditional Chinese medicine bath with no obvious side effects combined with case tracking management mode to form nursing measures to preve…

China130 participantsStarted 2021-01-01

Treatment: Chinese traditional medicine nursing combined with case tracking management, Health Education

RecruitingNot Applicable

NCT04979078

Photobiomodulation Therapy in the Management of Hand-foot Syndrome and Hand-foot Skin Reaction

Hand-foot syndrome (HFS) is a side effect of chemotherapy. HFS is characterized by redness, swelling, and pain on the palms of the hands and/or soles of the fee…

Belgium40 participantsStarted 2022-01-12

Treatment: Photobiomodulation therapy (PBMT)

All recent trials (55 shown)

CompletedNot Applicable

NCT05755646

Ice Plant Intensive Cream for the Prevention of Hand-Foot Syndrome in Breast Cancer: Pilot Randomized Controlled Trial

The present pilot study investigates the feasibility of a prospective larger confirmatory study on the efficacy of Dr. Hauschka Med Ice Plant Intensive Cream fo…

Germany15 participantsStarted 2023-03-10

Treatment: Ice Plant Intensive Cream plus Standard Care, Standard Care

Not Yet RecruitingNot Applicable

NCT07501442

Clinical Trial Evaluating the Efficacy and Safety of Uracil 0,5% Plasters in Oncology Patients Affected by Hand-foot Syn…

The goal of this clinical trial is to learn if The Uracil plaster works to treat mild HFS in adults under chemiotherapy. It will also learn about the safety .…

Italy80 participantsStarted 2026-07

Treatment: Uracil 0,5% plasters, lenitive cream

Palmar-Plantar Erythrodysesthesia Syndrome

Trial phase breakdown

Trial status

Actively recruiting — 6 trials

SHIELD: Sorafenib Hand-foot Syndrome Inhibition With Pre-Emptive Local Delivery of Topical Indomethacin

Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients

Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot S…

Effectiveness of an N-acetylcysteine and Urea-based Cream in Prevention of Capecitabine-induced HAND-foot Syndrome in Br…

The Preventive Effect of Chemotherapy-induced Hand-foot Syndrome

Photobiomodulation Therapy in the Management of Hand-foot Syndrome and Hand-foot Skin Reaction

All recent trials (55 shown)

Ice Plant Intensive Cream for the Prevention of Hand-Foot Syndrome in Breast Cancer: Pilot Randomized Controlled Trial

Clinical Trial Evaluating the Efficacy and Safety of Uracil 0,5% Plasters in Oncology Patients Affected by Hand-foot Syn…

Trial phase breakdown

Trial status

Actively recruiting — 6 trials

SHIELD: Sorafenib Hand-foot Syndrome Inhibition With Pre-Emptive Local Delivery of Topical Indomethacin

Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients

Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot S…

Effectiveness of an N-acetylcysteine and Urea-based Cream in Prevention of Capecitabine-induced HAND-foot Syndrome in Br…

The Preventive Effect of Chemotherapy-induced Hand-foot Syndrome

Photobiomodulation Therapy in the Management of Hand-foot Syndrome and Hand-foot Skin Reaction

All recent trials (55 shown)

Ice Plant Intensive Cream for the Prevention of Hand-Foot Syndrome in Breast Cancer: Pilot Randomized Controlled Trial

Clinical Trial Evaluating the Efficacy and Safety of Uracil 0,5% Plasters in Oncology Patients Affected by Hand-foot Syn…

TAR-0520 Gel in Hand and Foot Syndrome

The Efficacy and Safety of Mecobalamin in the Prevention of Capecitabine Induced Hand Foot Syndrome

Traditional Chinese Medicine Hand-Foot Soak for Chemotherapy-Induced Peripheral Neuropathy and Hand-Foot Syndrome

Efficacy and Safety of Moisturising Cream With or Without Vitamin E and Urea Cream in Palmar-plantar Erythrodysesthesia

Topical Diclofenac for Hand-Foot Syndrome Prevention in Colorectal and Gastric Cancer on Capecitabine (DICLO-HFS)

Photobiomodulation in the Treatment of Hand-foot Syndrome

Effectiveness of the Henna Application in Patients With Hand-Foot Syndrome: Nested Case-Control Study

Topical Cosmetic Products for Hand and Foot Syndrome

The Efficacy and Safety of Liangxue Ointment in the Treatment of Hand-foot Syndrome Caused by VEGFR-TKI Drugs

Effect of Topical Diclofenac on Clinical Outcome in Breast Cancer Patients Treated With Capecitabine

Efficacy of Extra Virgin Olive Oil (EVOO) Supplementation on Hand-Foot Syndrome Incidence in Patients With Capecitabine

The Efficacy of Acupuncture and Laser Acupuncture in Treating Chemotherapy or Target Therapy-induced Hand-foot Syndrome

Vitamin B6 Can Prevent Hand and Foot Syndrome in Cancer Patients Capecitabine Chemotherapy

Acetylated Natural Nucleotides in Treating Hand-foot Syndrome

Urea Cream Prevention for Capecitabine Associated Hand Foot Syndrome

Possible Protective Effect of Celecoxib Against Capecitabine Induced Hand and Foot Syndrome in Patients With Colorectal…

Study On Fatigue- And Hand-Foot Syndrome-Related Quality Of Life In Patients With Metastatic Renal Cell Carcinoma Receiv…

Hydration Based on Thoitaine, Aloe Vera and Calendula, in the Prevention of Hand-Foot Syndrome in Patients Using Capecit…