Opioid-Refractory Chronic Cancer-Related Pain

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Opioid-Refractory Chronic Cancer-Related Pain trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

All recent trials (4 shown)

Not Yet RecruitingEarly Phase 1

NCT07408193

The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.

This is a randomized, double-blinded, placebo-controlled, cross-over trial examining the effect of a series of two weekly intravenous infusions of lidocaine 4 m…

Greece24 participantsStarted 2026-03

Treatment: Lidocaine and Ketamine Infusion, Active Placebo (Midazolam) Infusion

WithdrawnPhase 2

NCT04666623

Compare the Efficacy and Safety of Intranasal Esketamine in Chronic Opioid Refractory Pain

This study is to assess the efficacy and safety of a four-week treatment with intranasal esketamine (56 mg) twice a week combined with opioid analgesic and adju…

Switzerland0Started 2020-11-25

Treatment: esketamine nasal spray, placebo nasal spray

TerminatedNot Applicable

NCT00726830

Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer

RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or ox…

United States1 participantsStarted 2009-03

Treatment: methadone hydrochloride, morphine sulfate

CompletedPhase 3

NCT00666211

Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain

RATIONALE: An Opioid Titration Order Sheet that allows healthcare providers to adjust the dose and schedule of pain medication may help improve pain treatment f…

United States98 participantsStarted 2005-05

Treatment: educational intervention, Titrated pain management