Malignant Soft Tissue Sarcoma

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Malignant Soft Tissue Sarcoma trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 38 trials

RecruitingPhase 1/2

NCT04901702

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

The phase I portion of this study is designed for children or adolescents and young adults (AYA) with a diagnosis of a solid tumor that has recurred (come back…

United States90 participantsStarted 2021-06-09

Treatment: Onivyde, Talazoparib

RecruitingPhase 3

NCT06422806

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Diffe…

This phase III trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patien…

United States365 participantsStarted 2024-09-11

Treatment: Biospecimen Collection, Diagnostic Imaging Testing

RecruitingPhase 2

NCT05985161

A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

The purpose of this study is to find out whether selinexor is an effective treatment for people who have a relapsed/refractory Wilms tumor, rhabdoid tumor, MPNS…

United States45 participantsStarted 2023-08-01

Treatment: Selinexor

RecruitingPhase 1/2

NCT04851119

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come ba…

United States147 participantsStarted 2021-11-08

Treatment: Biospecimen Collection, Dual X-ray Absorptiometry

RecruitingPhase 3

NCT05235165

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treat…

United States62 participantsStarted 2022-04-01

Treatment: Biospecimen Collection, Computed Tomography

RecruitingPhase 1/2

NCT07249905

Dose Escalation and Dose Expansion Study of MDX2003 in Patients With Different Types of Lymphoma

This study is designed to characterize the safety, tolerability, and anti-tumor activity of MDX2003 in patients with different types of lymphoma

Australia180 participantsStarted 2026-04-13

Treatment: MDX2003

All recent trials (100 shown)

Not Yet RecruitingPhase 2

NCT07576725

Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial

This phase II trial studies how well low dose, reduced frequency nivolumab works in treating patients with cancer that cannot be removed by surgery (unresectabl…

Uganda50 participantsStarted 2026-09-01

Treatment: Biospecimen Collection, Computed Tomography

Not Yet RecruitingPhase 1

NCT07443137

CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study)

This is a phase 1b clinical trial to assess the efficacy of rapcabtagene autoleucel (YTB323) administered at the recommended dose in adults with Large B Cell Ly…

Location not specified20 participantsStarted 2026-05

Treatment: Rapcabtagene autoleucel (YTB323)

Malignant Soft Tissue Sarcoma

Trial phase breakdown

Trial status

Actively recruiting — 38 trials

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Diffe…

A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Dose Escalation and Dose Expansion Study of MDX2003 in Patients With Different Types of Lymphoma

All recent trials (100 shown)

Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial

CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study)

Trial phase breakdown

Trial status

Actively recruiting — 38 trials

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Diffe…

A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Dose Escalation and Dose Expansion Study of MDX2003 in Patients With Different Types of Lymphoma

All recent trials (100 shown)

Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial

CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study)

P-CD19CD20-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With B Cell Malignancies

DPX-Survivac and Checkpoint Inhibitor in DLBCL

A Study to Evaluate the Safety and Efficacy of SCTB35 in Combination With Gemcitabine and Oxaliplatin in Patients With R…

Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a…

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid T…

Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene A…

Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly D…

Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pe…

PET/CT and Lymph Node Mapping in Finding Lymph Node Metastasis in Patients With High-Risk Endometrial Cancer

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

Natural History Study of Patients With Neurofibromatosis Type I

Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1

Anti-CD22 Chimeric Receptor T Cells in Pediatric and Young Adults With Recurrent or Refractory CD22-expressing B Cell Ma…

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expre…

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovaria…

Study on the Treatment of Double/Triple-hit DLBCL With Chidamide and Lisaftoclax in Combination With Pola-R-CHP

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced…