Lower Limb Amputation Below Knee

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Lower Limb Amputation Below Knee trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 12 trials

RecruitingNot Applicable

NCT05124652

An Automatically Adjusting Prosthetic Socket for People With Transtibial Amputation

People with leg amputations often experience daily changes in the size (volume) of their residual limb. These daily changes can cause a prosthesis to fit poorly…

United States100 participantsStarted 2021-10-18

Treatment: Auto Adjusting Prosthesis

RecruitingNot Applicable

NCT05884203

Improving Prosthetic Provision in Rural Communities: Limb Scanning With Caregiver Assistance

When the prosthetic socket of a Veteran with a lower limb amputation no longer fits or is damaged beyond repair, a new prosthetic socket is warranted. The provi…

United States25 participantsStarted 2023-07-01

Treatment: Caregiver socket, Prosthetist socket

RecruitingNot Applicable

NCT06452186

Restoration of Normative Postural Control

The objective of this proposal is to investigate the effects of training to use direct electromyographic (dEMG) control of a powered prosthetic ankle on transti…

United States50 participantsStarted 2023-10-01

Treatment: direct EMG controlled prosthetic ankle, PT guided prosthetic training

RecruitingNot Applicable

NCT07324109

Clinical Application Observation on the Evaluation of Phantom Limb Pain With the Suralis System

This study tests whether a vibration-based feedback device (Suralis) can reduce phantom limb pain in people with lower-leg amputations over 3 weeks. Participant…

Germany20 participantsStarted 2025-04-01

Treatment: Vibrotactile sensory feedback

RecruitingNot Applicable

NCT06419920

Prosthetic Performance Enhancement Trial

The purpose of this research is to determine the feasibility of an uneven terrain walking program for lower limb prosthesis users. The training is designed to i…

United States35 participantsStarted 2025-06-26

Treatment: Flat terrain locomotor training, Uneven terrain locomotor training

RecruitingNot Applicable

NCT06711588

Automatic Prosthetic Foot Stiffness Modulation to Improve Balance

The goal of this clinical trial is to identify prosthesis stiffness that optimizes balance control in individuals with below knee amputations. The main question…

United States20 participantsStarted 2024-12-19

Treatment: As-prescribed stiffness, Two categories stiffer than the as-prescribed stiffness

All recent trials (49 shown)

WithdrawnNot Applicable

NCT07491588

Context- and Terrain-aware Gait Analysis

The average lifespan of individuals in many developed countries is increasing. This factor paired with the increase in global population has the potential to pu…

Location not specified0Started 2025-03-01

Treatment: All-terrain Gait Analysis System

Not Yet RecruitingNot Applicable

NCT07448350

TENS for Restoring Somatotopic Sensory Feedback in Lower Limb Amputees and Improving Phantom Limb Perception

The aim of the study is to evaluate the changes induced by a course of Transcutaneous Electrical Nerve Stimulation (TENS) treatment on the perception of phantom…

Italy15 participantsStarted 2026-03-01

Treatment: Transcutaneal Electrical Nerve Stimulation

Lower Limb Amputation Below Knee

Trial phase breakdown

Trial status

Actively recruiting — 12 trials

An Automatically Adjusting Prosthetic Socket for People With Transtibial Amputation

Improving Prosthetic Provision in Rural Communities: Limb Scanning With Caregiver Assistance

Restoration of Normative Postural Control

Clinical Application Observation on the Evaluation of Phantom Limb Pain With the Suralis System

Prosthetic Performance Enhancement Trial

Automatic Prosthetic Foot Stiffness Modulation to Improve Balance

All recent trials (49 shown)

Context- and Terrain-aware Gait Analysis

TENS for Restoring Somatotopic Sensory Feedback in Lower Limb Amputees and Improving Phantom Limb Perception

Trial phase breakdown

Trial status

Actively recruiting — 12 trials

An Automatically Adjusting Prosthetic Socket for People With Transtibial Amputation

Improving Prosthetic Provision in Rural Communities: Limb Scanning With Caregiver Assistance

Restoration of Normative Postural Control

Clinical Application Observation on the Evaluation of Phantom Limb Pain With the Suralis System

Prosthetic Performance Enhancement Trial

Automatic Prosthetic Foot Stiffness Modulation to Improve Balance

All recent trials (49 shown)

Context- and Terrain-aware Gait Analysis

TENS for Restoring Somatotopic Sensory Feedback in Lower Limb Amputees and Improving Phantom Limb Perception

Lower Limb Prostheses for Individuals Who Carry Infants, Toddlers, and Other Loads

Adjustable Prosthetic Sockets

Prosthetic Satisfaction, Body Image, and ICF Outcomes After Amputation

Adherence and Perspiration While Wearing Lower Limb Prostheses

Asymmetry of the Center of Pressure During Gait After Amputation of Lower Limbs

Pivot-Flex Foot: Optimal Coupling Ratio Between Transverse and Sagittal-plane Motions Using a Torsionally Adaptive Prost…

Skin Temperature Perception and Prosthetic Thermoregulation

Hyperbaric Oxygen and Outcome After Below Knee Amputations

Skew Flap vs Long Posterior Flap for Below Knee Amputation Early and Short- Term Outcomes

Effects of Prosthesis Training on Pain, Prosthesis Satisfaction and Ambulatory Status of Lower Limb Amputees

VR to Evaluate Phantom Limb Pain

The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD

Socket Cooling Effectiveness Take Home Study

Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot

NIH Release/Relock Socket

Enhancing Abilities in Amputees and Patients With Peripheral Neuropathy Through Restoration of Sensory Feedback

Pilot Study to Assess the Use of Spy Elite for Assessment of Amputation Healing

Safety and Efficacy of Vibro-tactile Feedback for Patients Who Underwent Lower Limb Amputation