Liposarcomas, Dedifferentiated

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Liposarcomas, Dedifferentiated trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 12 trials

RecruitingPhase 3

NCT06422806

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Diffe…

This phase III trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patien…

United States365 participantsStarted 2024-09-11

Treatment: Biospecimen Collection, Diagnostic Imaging Testing

RecruitingPhase 1/2

NCT06239272

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and S…

The study participant has been diagnosed with non-rhabdomyosarcoma (NRSTS). Primary Objectives Intermediate-Risk * To estimate the 3-year event-free survival…

United States139 participantsStarted 2024-03-27

Treatment: Surgical resection, Proton beam radiation therapy

RecruitingPhase 1/2

NCT06975293

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants…

This early phase oncology trial will be conducted at various study centers to investigate the safety, tolerability, and antitumor activity of STC-15 (a METTL3 i…

United States107 participantsStarted 2025-05-05

Treatment: STC-15 in combination with toripalimab, STC-15 monotherapy

RecruitingPhase 1

NCT05711615

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Adv…

This phase I trial tests the safety, side effects, and best dose of combination therapy with liposomal doxorubicin and peposertib in treating patients with sarc…

United States30 participantsStarted 2024-02-06

Treatment: Biopsy Procedure, Biospecimen Collection

RecruitingPhase 1/2

NCT06498648

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tis…

This phase I/II trial tests the side effects and best dose of abemaciclib when added to gemcitabine and compares the effectiveness of that treatment to the usua…

United States74 participantsStarted 2026-03-18

Treatment: Abemaciclib, Biopsy Procedure

RecruitingPhase 1/2

NCT06843967

A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

The purpose of this study is to find out whether mirdametinib in combination with palbociclib is an effective and safe treatment for people with metastatic, rec…

United States54 participantsStarted 2025-02-19

Treatment: Mirdametinib, Palbociclib

All recent trials (45 shown)

Active — Not RecruitingPhase 2

NCT04668300

Oleclumab and Durvalumab for the Treatment of Recurrent, Refractory, or Metastatic Sarcoma

This phase II trial investigates how well oleclumab and durvalumab work in treating patients with sarcoma that has come back (recurrent) or does not respond to…

United States75 participantsStarted 2020-11-26

Treatment: Durvalumab, Oleclumab

Active — Not RecruitingPhase 1

NCT04420975

Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

This phase I trial studies the side effects of BO-112 when given together with nivolumab before surgery in treating patients with soft tissue sarcoma that can b…

United States14 participantsStarted 2020-10-14

Treatment: Definitive Surgical Resection, Nanoplexed Poly I:C BO-112

Liposarcomas, Dedifferentiated

Trial phase breakdown

Trial status

Actively recruiting — 12 trials

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Diffe…

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and S…

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants…

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Adv…

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tis…

A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

All recent trials (45 shown)

Oleclumab and Durvalumab for the Treatment of Recurrent, Refractory, or Metastatic Sarcoma

Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

Trial phase breakdown

Trial status

Actively recruiting — 12 trials

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Diffe…

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and S…

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants…

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Adv…

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tis…

A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

All recent trials (45 shown)

Oleclumab and Durvalumab for the Treatment of Recurrent, Refractory, or Metastatic Sarcoma

Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferen…

Brightline-1: A Study to Compare Brigimadlin (BI 907828) With Doxorubicin in People With a Type of Cancer Called Dediffe…

Study on Trabectedin in Combination With Pioglitazone in Patients Myxoid Liposarcomas With Stable Disease After T Alone.

Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma

Brightline-4: A Study to Test How Well Brigimadlin is Tolerated by People With a Type of Cancer Called Dedifferentiated…

TQB3616 Capsules in the Treatment of Dedifferentiated Liposarcoma

A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma

Palbociclib and INCMGA00012 in People With Advanced Liposarcoma

Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas

Real-world Study of Dedifferentiated Liposarcoma Patients in China

Open-Label Study of the CDK4/6 Inhibitor SPH4336 in Subjects With Locally Advanced or Metastatic Liposarcomas

Study of Abemaciclib in Dedifferentiated Liposarcoma

Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)

Treatment of Milademetan Versus Trabectedin in Patient With Dedifferentiated Liposarcoma

SARC041: Study of Abemaciclib Versus Placebo in Patients with Advanced Dedifferentiated Liposarcoma

First-line Treatment of Advanced/unresectable DDLPS

Phase 1, First-in-human Study of Oral TP-1287 in Patients with Advanced Solid Tumors

Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Ext…