Infections, Cytomegalovirus

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Infections, Cytomegalovirus trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 45 trials

RecruitingPhase 1

NCT06118515

A Safety Assessment of Oral Letermovir in Infants With Symptomatic Congenital Cytomegalovirus

This is a Phase 1 single-arm open-label study of letermovir in neonates with symptomatic congenital Cytomegalovirus (CMV) disease. There will be two groups enro…

United States12 participantsStarted 2025-02-19

Treatment: Letermovir

RecruitingPhase 4

NCT07569653

Letermovir Prophylaxis Duration Guided by CMV-Specific T-cell Monitoring After Allo-HSCT.

The purpose of this study is to evaluate the efficacy and safety of a personalized strategy for discontinuing Letermovir (a drug used to prevent Cytomegalovirus…

China120 participantsStarted 2025-10-30

Treatment: CMV-Specific T-cell Guided Letermovir Discontinuation, Standard Letermovir Prophylaxis

RecruitingPhase 3

NCT05711667

A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patien…

This phase III single arm trial determines whether taking prophylactic letermovir will reduce the likelihood of infection with cytomegalovirus (CMV) in children…

United States105 participantsStarted 2024-07-11

Treatment: Biospecimen Collection, Letermovir

RecruitingNot Applicable

NCT01011712

The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known Immunoco…

Background: * Infections caused by viruses are common causes of illnesses: the common cold, many ear infections, sore throats, chicken pox, and the flu are cau…

United States600 participantsStarted 2009-10-01

RecruitingPhase 1

NCT05101213

Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus S…

This phase I trial tests the feasibility and safety of genetically modified cytotoxic T-lymphocytes in controlling infections caused by adenovirus (ADV), BK vir…

United States30 participantsStarted 2023-01-06

Treatment: Virus-specific Cytotoxic T-lymphocytes

RecruitingEarly Phase 1

NCT03665675

Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT

This trial studies the side effects and how well allogeneic cytomegalovirus-specific cytotoxic T lymphocytes (donor cytomegalovirus \[CMV\] specific cytotoxic T…

United States20 participantsStarted 2020-11-07

Treatment: Allogeneic Cytomegalovirus-Specific Cytotoxic T lymphocytes, Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes

All recent trials (100 shown)

Not Yet RecruitingPhase 4

NCT07571135

Letermovir vs Valganciclovir in CMV R+ Kidney Transplant

The purpose of this study is to find out whether letermovir can help prevent cytomegalovirus (CMV) infection in kidney transplant recipients who are CMV seropos…

United States300 participantsStarted 2026-05

Treatment: Letermovir, Valganciclovir CMV Prophylaxis

Not Yet RecruitingPhase 4

NCT07570433

HORUS-Cytomegalovirus Open Proof-of-concept Exploratory Trial

Cytomegalovirus (CMV) remains a significant cause of morbidity and mortality following organ transplantation. Cell-mediated immunity plays a crucial role in co…

France, Spain, Switzerland100 participantsStarted 2026-04

Treatment: 50% reduction in the dose of MPA, Switch from MPA to a mammalian target of rapamycin inhibitor (mTORi), together with an adapted dose of tacrolimus

Infections, Cytomegalovirus

Trial phase breakdown

Trial status

Actively recruiting — 45 trials

A Safety Assessment of Oral Letermovir in Infants With Symptomatic Congenital Cytomegalovirus

Letermovir Prophylaxis Duration Guided by CMV-Specific T-cell Monitoring After Allo-HSCT.

A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patien…

The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known Immunoco…

Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus S…

Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT

All recent trials (100 shown)

Letermovir vs Valganciclovir in CMV R+ Kidney Transplant

HORUS-Cytomegalovirus Open Proof-of-concept Exploratory Trial

Trial phase breakdown

Trial status

Actively recruiting — 45 trials

A Safety Assessment of Oral Letermovir in Infants With Symptomatic Congenital Cytomegalovirus

Letermovir Prophylaxis Duration Guided by CMV-Specific T-cell Monitoring After Allo-HSCT.

A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patien…

The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known Immunoco…

Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus S…

Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT

All recent trials (100 shown)

Letermovir vs Valganciclovir in CMV R+ Kidney Transplant

HORUS-Cytomegalovirus Open Proof-of-concept Exploratory Trial

Dose-Finding Trial to Evaluate the Safety and Immunogenicity of Cytomegalovirus (CMV) Vaccine mRNA-1647 in Healthy Adult…

Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts

A Study of Cytomegalovirus Disease Epidemiology in Pediatric and Adult Liver Transplant Recipients in China

Letermovir for CMV Prevention After Lung Transplantation

Systemic and Topical Antiviral Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes - Trials I and II

Prenatal Behavioral Intervention to Prevent Maternal Cytomegalovirus (CMV) in Pregnancy

Prenatal Treatment of Congenital Cytomegalovirus Infection With Letermovir Randomized Against Valaciclovir - CYMEVALIII…

CMV T Cell Immunity in Pediatric Solid Organ Transplant Recipients

Diagnosis of Congenital CMV Infection in Neonates Who Failed Newborn Hearing Screening

Renal Ex Vivo SYN002 Perfusion to Eliminate CMV Transmission

A Study of Modified mRNA Vaccines in Healthy Adults

Evaluation of Long-term Efficacy of 4 to 6-month Course Antiviral Therapy for Neurodevelopmental Impairments Caused by C…

To Investigate Safety, Reactogenicity and Immunogenicity of VIR-1388 Compared With Placebo in Participants Without HIV

Reducing Post-Letermovir CMV Infection: Efficacy of an Immune-Reconstitution-Based Scoring System to Guide Prophylaxis D…

A Study of Safety and Immune Response to Different Doses of a Cytomegalovirus Vaccine in Healthy Adults

Dried Blood Spot Testing of CMV Detection in HCT Recipients

Valganciclovir Prophylaxis Versus Preemptive Therapy for Cytomegalovirus in Living Donor Kidney Transplant Recipients

Donor Cytomegalovirus-Specific Cytotoxic T-Lymphocytes in Treating Patients With a Persistent Cytomegalovirus Infection