Infantile Spasms

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Infantile Spasms trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 7 trials

RecruitingPhase 2

NCT04289467

Treatment of Refractory Infantile Spasms With Fenfluramine

This is a phase II clinical trial in which children with refractory infantile spasms (also called epileptic spasms or West syndrome) will be treated with fenflu…

United States10 participantsStarted 2023-06-16

Treatment: Fenfluramine

RecruitingNot Applicable

NCT05126914

Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and Adolescents

Rare epilepsies as a whole account for 20-30% of epilepsies, but knowledge about prognostic factors is currently limited. This means that it is difficult to pro…

France1,000 participantsStarted 2025-12-11

RecruitingPhase 1

NCT06700811

Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies

Epileptic spasms (ES) are a predominantly infantile seizure type observed frequently in certain genetic disorders. Ketogenic diet (high ratio of fat to carbohyd…

United States10 participantsStarted 2025-08-11

Treatment: Ketogenic diet

RecruitingPhase 2

NCT06819670

A Study to Prevent Infantile Spasms Relapse

After initially successful treatment, many children with infantile spasms unfortunately have a relapse, and relapse is linked to poor long-term outcomes such as…

United States40 participantsStarted 2025-05-05

Treatment: Prednisolone, Famotidine

RecruitingNot Applicable

NCT06266234

Characterization by Automated System on Infantile Spasmes

Infantile spasms are defined by the occurrence of epileptic episodes characterized by the appearance of very specific motor seizures, made up of rapid, repeated…

France5,000 participantsStarted 2024-02-01

RecruitingPhase 2/3

NCT06201897

Cortical Excitability in West Syndrome Using Transcranial Magnetic Stimulation

Currently, no literature is available regarding degree of cortical excitability and its correlation with various epileptic syndromes and disorders such as West…

India40 participantsStarted 2024-03

Treatment: ACTH/Oral Steroids

All recent trials (48 shown)

CompletedNot Applicable

NCT06315829

Artificial Intelligence-based Video Analysis to Detect Infantile Spasms

Infantile spasms are a type of seizure linked to developmental issues. Unfortunately, they are often misdiagnosed, causing delays in treatment. The purpose of t…

United States61 participantsStarted 2024-08-26

Treatment: Spasm Vision

Active — Not RecruitingPhase 3

NCT05064878

A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.

This is a Phase 3 Study to examine the efficacy and safety of ZX008 in children and adults with cyclin-dependent kinase like-5 (CDKL5) deficiency disorder (CDD)…

United States87 participantsStarted 2022-03-08

Treatment: Fenfluramine, Placebo

Infantile Spasms

Trial phase breakdown

Trial status

Actively recruiting — 7 trials

Treatment of Refractory Infantile Spasms With Fenfluramine

Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and Adolescents

Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies

A Study to Prevent Infantile Spasms Relapse

Characterization by Automated System on Infantile Spasmes

Cortical Excitability in West Syndrome Using Transcranial Magnetic Stimulation

All recent trials (48 shown)

Artificial Intelligence-based Video Analysis to Detect Infantile Spasms

A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.

Trial phase breakdown

Trial status

Actively recruiting — 7 trials

Treatment of Refractory Infantile Spasms With Fenfluramine

Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and Adolescents

Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies

A Study to Prevent Infantile Spasms Relapse

Characterization by Automated System on Infantile Spasmes

Cortical Excitability in West Syndrome Using Transcranial Magnetic Stimulation

All recent trials (48 shown)

Artificial Intelligence-based Video Analysis to Detect Infantile Spasms

A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.

The Effect of Spa and Massage on Babies on Colic Symptoms

Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Drave…

Clinical Trial on 7-day Followed by Maintenance Therapy for 10 Weeks vs. 14-day and no Maintenance Course of Prednisolon…

Tricaprilin Infantile Spasms Pilot Study

A Study of Orally Administered JBPOS0101 in Refractory Infantile Spasms Patients

Ketogenic Diet vs ACTH for the Treatment of Children With West Syndrome

Open-label Extension to Protocol 1042-0500

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

Modified Atkins Diet Versus Topiramate In Children With Epileptic Spasms Refractory To Hormonal Treatment: A Randomized…

A Study to Assess Cannabidiol Oral Solution With Vigabatrin as Initial Therapy in Participants With Infantile Spasms

A Randomized, Controlled Trial of Ganaxolone in Patients With Infantile Spasms

Cannabidiol in Children With Refractory Epileptic Encephalopathy

A Study to Evaluate Safety and Efficacy of AMZ002 Treatment, Compared With Vigabatrin in Participants With Infantile Spa…

Trial of Cannabidiol (CBD; GWP42003-P) for Infantile Spasms (GWPCARE7)

Phase 3 Trial of Cannabidiol (CBD; GWP42003-P) for Infantile Spasms: Open-label Extension Phase (GWPCARE7)

Decreasing Parental Stress of Caregivers of Infants With Infantile Spasms by Using Telemedicine Technology

Genetic Studies in Patients and Families With Infantile Spasms

A Novel Approach to Infantile Spasms