Hypertrophy, Left Ventricular

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Hypertrophy, Left Ventricular trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 30 trials

RecruitingPhase 2

NCT06092034

A Gene Therapy Study of RP-A501 in Male Patients With Danon Disease

This is a single arm Phase 2 trial to evaluate the efficacy and safety of RP-A501, a recombinant adeno-associated virus serotype 9 (AAV9) containing the human l…

United States, Germany, Italy14 participantsStarted 2023-09-05

Treatment: RP-A501

RecruitingPhase 2

NCT06655480

Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF

Patients with advanced heart failure with preserved ejection fraction (HFpEF) will be randomly assigned in open-label multicenter study to receive triple combin…

Russia50 participantsStarted 2025-03-18

Treatment: [ARNI + SGLTi + AMR], [SGLTi + previously taken RAAS blocker]

RecruitingNot Applicable

NCT06427304

Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure

Tne aim purpose of this observational, multicentre and propective study is to determine the prevalence of cardiac amyloidosis in geriatric patients aged 80 year…

France637 participantsStarted 2024-07-01

RecruitingNot Applicable

NCT06844032

Predictors of Poor Prognosis in HFpEF

Patients with HFpEF who have undergone meticulous clinical and instrumental evaluation (including diastolic exercise testing) between 2013 and 2020, will be fol…

Russia500 participantsStarted 2022-01-31

RecruitingPhase 4

NCT05593055

Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension

The investigators' goal is to show that in hypertensive men and women with left ventricular hypertrophy (LVH) treatment with a mineralocorticoid receptor (MR) a…

United States75 participantsStarted 2023-08-25

Treatment: Eplerenone, Chlorthalidone

RecruitingNot Applicable

NCT07483125

Valsalva SBP Drop and LVOT Obstruction

This study aimed to evaluate the efficacy of non-invasive dynamic blood pressure monitoring in assessing left ventricular outflow tract obstruction in patients…

China800 participantsStarted 2025-12-01

Treatment: participants are not assigned an intervention as part of the study

All recent trials (100 shown)

Not Yet RecruitingPhase 2

NCT07539259

A Randomised Controlled Trial to Establish Whether Dapagliflozin and Spironolactone in Patients With Severe Aortic Steno…

This trial aims to improve the heart health of people with a narrowed aortic valve called aortic stenosis (AS) who have their valve replaced through aortic valv…

Location not specified445 participantsStarted 2026-12

Treatment: Dapagliflozin (DAPA), Spironolactone (drug)

CompletedNot Applicable

NCT07529938

Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy

This retrospective cohort study aims to evaluate the clinical efficacy and safety of mavacamten in adult patients with obstructive hypertrophic cardiomyopathy (…

China222 participantsStarted 2024-01-01

Treatment: mavacamten

Hypertrophy, Left Ventricular

Trial phase breakdown

Trial status

Actively recruiting — 30 trials

A Gene Therapy Study of RP-A501 in Male Patients With Danon Disease

Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF

Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure

Predictors of Poor Prognosis in HFpEF

Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension

Valsalva SBP Drop and LVOT Obstruction

All recent trials (100 shown)

A Randomised Controlled Trial to Establish Whether Dapagliflozin and Spironolactone in Patients With Severe Aortic Steno…

Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy

Trial phase breakdown

Trial status

Actively recruiting — 30 trials

A Gene Therapy Study of RP-A501 in Male Patients With Danon Disease

Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF

Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure

Predictors of Poor Prognosis in HFpEF

Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension

Valsalva SBP Drop and LVOT Obstruction

All recent trials (100 shown)

A Randomised Controlled Trial to Establish Whether Dapagliflozin and Spironolactone in Patients With Severe Aortic Steno…

Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy

A Health Coach-Led Digital Lifestyle Intervention (HEALDI)

AI-based Echocardiography for Detection of Cardiac Amyloidosis

CMR T1 Mapping for Diagnosis of Cardiac Amyloidosis

Catheter Ablation Versus Anti-arrhythmic Drugs for Ventricular Tachycardia

A Study to Evaluate the Effect of Venglustat Tablets on Left Ventricular Mass Index in Male and Female Adult Participant…

SGLT2 Inhibition in Hemodialysis

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM

A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

Left Ventricular Hypertrophy in CKD Patients

The Therapeutic Value of Mavacamten in Hypertrophic Cardiomyopathy With Mid-to-Apical Left Ventricular Obstruction

ReNEW Clinic Cohort Study

SMCs With LVH Compared to HCM

Towards Understanding the Phenotype of Cardiovascular Disease in CKD - TRUE-Type-CKD Study

The COlchicine HypERtENsion Trial

NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study

Cardea SOLOTM for Paroxysmal Atrial Fibrillation Diagnosis in ESUS Patients With Left Atrial Enlargement

Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS

Positron Emission Tomography to Assess the Effect of Camzyos on Ischaemia in HOCM: PEACH Trial