High Cholesterol/Hyperlipidemia

Clinical trial pipeline · Data from ClinicalTrials.gov

See which High Cholesterol/Hyperlipidemia trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 36 trials

RecruitingNot Applicable

NCT06546137

National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Un…

The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data…

Brazil1,211 participantsStarted 2025-04-30

Treatment: whole genome sequencing

RecruitingNot Applicable

NCT00353782

Causes and Natural History of Dyslipidemias

This study will evaluate people with dyslipidemias - disorders that affect the fat content in the blood. Fats, or lipids, such as cholesterol and triglycerides,…

United States2,000 participantsStarted 2003-10-14

RecruitingPhase 3

NCT07037771

A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)

This multicenter, randomized, placebo-controlled study will evaluate the efficacy and safety of zodasiran subcutaneous (SC) injection in subjects 12 years of ag…

United States, Australia60 participantsStarted 2025-06-17

Treatment: zodasiran Injection, Placebo

RecruitingNot Applicable

NCT07447648

Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Cor…

This observational, multicenter, retrospective and prospective study aims to evaluate the impact of intensified lipid-lowering therapy including Evinacumab on c…

France, Italy52 participantsStarted 2026-04-30

RecruitingPhase 2

NCT04941599

2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)

The Investigators will test the hypothesis that 2-HOBA will reduce modification of HDL and LDL and improve HDL function in humans with heterozygous FH. The Inve…

United States72 participantsStarted 2024-02-14

Treatment: 2-Hydroxybenzylamine, Placebo

RecruitingPhase 3

NCT05682378

Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION…

The purpose of this open-label, single arm, multicenter extension study is to evaluate the long-term safety and tolerability of inclisiran in participants with…

United States195 participantsStarted 2023-02-10

Treatment: Inclisiran

All recent trials (100 shown)

CompletedPhase 3

NCT07564726

Efficacy and Safety of Ezetimibe/Rosuvastatin and Amlodipine Patients With High Blood Pressure and High Cholesterol

The goal of this clinical trial is to test whether one pill that combines ezetimibe, rosuvastatin, and amlodipine can safely lower cholesterol and blood pressur…

South Korea163 participantsStarted 2022-08-05

Treatment: Amlodipine, Ezetimibe/Rosuvastatin

CompletedNot Applicable

NCT00001154

Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Researchers plan to study the fat-rich particles, called lipoproteins, which circulate in the blood. This study is designed to improve understanding of normal,…

United States759 participantsStarted 1976-09-03

High Cholesterol/Hyperlipidemia

Trial phase breakdown

Trial status

Actively recruiting — 36 trials

National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Un…

Causes and Natural History of Dyslipidemias

A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)

Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Cor…

2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)

Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION…

All recent trials (100 shown)

Efficacy and Safety of Ezetimibe/Rosuvastatin and Amlodipine Patients With High Blood Pressure and High Cholesterol

Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Trial phase breakdown

Trial status

Actively recruiting — 36 trials

National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Un…

Causes and Natural History of Dyslipidemias

A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)

Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Cor…

2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)

Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION…

All recent trials (100 shown)

Efficacy and Safety of Ezetimibe/Rosuvastatin and Amlodipine Patients With High Blood Pressure and High Cholesterol

Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Evaluation of Lipoproteins

Virtual Lifestyle Intervention for Weight Management and Cardiovascular Heal

VIsualization of Coronary Artery Disease for Modification of RISK Factors

A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of VSA003 in Chinese HoFH Patients

Vascular Intervention Strategies Trial for Alzheimer's

Impact of Phytosterol-Rich Extract on Lipid Profile

Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia

Cardiovascular Evaluation of Patients With High Cholesterol and Normal Volunteers

An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA-FH)

Moderate-Intensity Statin Plus Ezetimibe in CKD and ASCVD

Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes

A Real-World Study of Long-Term Adherence and Persistence to Inclisiran, Evolocumab, and Alirocumab

Specified Drug-use Survey of Leqvio for s.c. Injection.

A Non-interventional Implementation Study to Evaluate Treatment With Inclisiran (Leqvio®) and Other Lipid Lowering Treat…

Lipid Management in Renal Transplant Recipients Using Evolocumab.

Screening for Cardiac and Cardiac-associated Pathology Using Single-channel Electrocardiogram

Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease

Limosilactobacillus Fermentum CRL 1446 - CONICET CASASCO