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Endophthalmitis

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Endophthalmitis trials you may qualify for

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Clinical Trial Compass

Data sourced from ClinicalTrials.gov and OpenFDA. For informational purposes only. Always consult your healthcare provider.

Not medical advice.

75

Total trials

3

Actively recruiting

7

Phase 3 trials

42

Completed

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

RecruitingNot Applicable

Nanopore Sequencing in Ophthalmology

In this pilot study, the feasibility of the Oxford Nanopore MinION to identify pathogens from vitrectomy samples in eyes with endophthalmitis shall be assessed.…

Austria20 participantsStarted 2022-04-22

RecruitingNot Applicable

Vascular Changes Associated With Endophthalmitis.

This study aims to describe and investigate vascular changes associated with exogenous endophthalmitis, as well as to create a photo library where they are evid…

Mexico71 participantsStarted 2024-11-01

Treatment: Multimodal imaging findings

RecruitingNot Applicable

Complex Ocular Infection, Optimization of Microbiological Diagnosis

The purpose of this study is to evaluate the impact of different technique to optimize the microbiological diagnosis of the COI. * Metagenomic for the endophta…

France153 participantsStarted 2023-11-21

Treatment: NGS for endohtalmitis / Multiplex PCR for keratitis

All recent trials (75 shown)

CompletedNot Applicable

First-line Surgical Versus Medical Treatment: A Retrospective Study From 2014 to 2024 in Brest (BRESTE)

The goal of this observational cohort study is to evaluate the impact of early pars plana vitrectomy (PPV) on visual outcomes in adults diagnosed with acute end…

France170 participantsStarted 2025-01-01

Treatment: Early pars plana vitrectomy (PPV) with intravitreal antibiotics

CompletedNot Applicable

Endophthalmitis After Intravitreal Injection of Antiangiogenic Agents or Corticosteroids, a Cohort Study of the French P…

Intravitreal injections (IVI) of antiangiogenic agents (AA) have revolutionized the management of age-related macular degeneration (AMD) and diabetic macular ed…

Location not specified360,000 participantsStarted 2016-01-01

Treatment: Data collection

Active — Not RecruitingNot Applicable

Targeting Immunosuppressive Treatment for Non-infectious Uveitis Using Aqueous Humor Cytokine Profiles

This multicenter, prospective, interventional, non-pharmacological study aims to investigate whether the intraocular cytokine profile is associated with the the…

Italy220 participantsStarted 2025-11-15

Treatment: to improve clinical practice in treatment of non-infective uveitis

Not Yet RecruitingPhase 2/3

Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery

Intracameral injection of 0.1% moxifloxacin solution after cataract surgery to prevent endophthalmitis

United States60,000 participantsStarted 2026-06-01

Treatment: Moxifloxacin, Placebo

Active — Not RecruitingNot Applicable

Demographics and Clinical Characteristics of Ocular Inflammatory Diseases in Singapore

This is a retrospective study analyzing demographics, clinical characteristics, treatment received, and outcomes of ocular inflammatory diseases that presented…

Singapore200 participantsStarted 2025-08-19

Treatment: No Intervention: Observational Cohort

CompletedNot Applicable

A Feasibility Randomised Controlled Trial of Early Vitrectomy for Post-operative Exogenous Endophthalmitis

This randomised clinical trial will explore the feasibility and acceptability of carrying out early vitrectomy surgical treatment compared to standard treatment…

United Kingdom63 participantsStarted 2021-08-12

Treatment: Vitrectomy, Intravitreal antibiotics

CompletedPhase 4

Bromfenac Versus Dexamethasone After Cataract Surgery

The aim of the study is to compare bromfenac to dexamethasone eye drops to control inflammation after cataract surgery. Inflammation in the anterior chamber of…

Italy92 participantsStarted 2017-10-16

Treatment: Bromfenac 0.09 % Ophthalmic Solution, Dexamethasone 0.1% ophthalmic suspension

CompletedPhase 2

RTA 408 Ophthalmic Suspension for the Treatment of Ocular Inflammation and Pain Following Ocular Surgery

This study assesses the efficacy and safety of two concentrations of RTA 408 Ophthalmic Suspension in the treatment of patients who have inflammation and pain f…

United States109 participantsStarted 2014-02-28

Treatment: Omaveloxolone Ophthalmic Suspension 1.0%, Omaveloxolone Opthalmic Suspension 0.5%

CompletedNot Applicable

Compare PPV With and Without Silicone Oil in Managing Postoperative Endophthalmitis

Comparing PPV with and without silicone oil in managing postoperative endophthalmitis

Egypt40 participantsStarted 2024-01-20

Treatment: Pars plana Vitrectomy, Silicone Oil

CompletedNot Applicable

Clinical Features and Visual Prognosis of Infectious Endophthalmitis

The aim of this observational study was to retrospectively examine the clinical data of patients with infectious endophthalmitis and to analyse their clinical c…

China100 participantsStarted 2024-06-01

TerminatedPhase 3

Study Evaluating the Efficacy and Safety of OCS-01 Eye Drops in Subjects Following Cataract Surgery

The goal of this clinical trial is to evaluate the efficacy and safety of OCS-01 in treating inflammation and pain in subjects following cataract surgery.

United States117 participantsStarted 2023-12-18

Treatment: Dexamethasone Ophthalmic Suspension, Vehicle of OCS-01

CompletedEarly Phase 1

To Compare the Safety and Efficacy of Intracameral Levofloxacin and Intracameral Cefazolin in Reducing Rates of Endophth…

Patients with senile cataracts undergoing phacoemulsification were assigned to receive intracameral levofloxacin (0.1ml/0.5mg) or intracameral cefazolin (0.1ml/…

Singapore50 participantsStarted 2022-01-01

Treatment: Safety of intracameral levofloxacin in cataract surgery, Use of intracameral cefazolin in cataract surgery

Not Yet RecruitingNot Applicable

Evaluation and Risk Factors of Post-traumatic Endophthalmitis

1. identify the incidence of post-traumatic endophthalmitis and the related risk factors influencing its development. 2. study the clinical- microbiological pro…

Location not specified41 participantsStarted 2024-11-10

Treatment: ophthalmic saline eye drops, Saline

Not Yet RecruitingPhase 1

Efficacy and Safety of Topical Cyclosporine 0.05% and Lifitgrast on the Ocular Surface Symptom After Photorefractive Ker…

The goal of this clinical trial is to compare the administration of 2 drugs, cyclosporine 0.05% (Restasis) and Lifitgrast (Xiidra) before PRK, in reducing the o…

Iran150 participantsStarted 2024-10-30

Treatment: Group 1 drug, Group 2: Drug and placebo

CompletedNot Applicable

Evaluation do Early Pars Plana Vitrectomy in Acute Endophthalmitis

Our study will evaluate the efficacy of early PPV in acute endophthalmitis and attempt to prove its greater effectiveness for combating infection when compared…

Brazil25 participantsStarted 2019-01-01

Treatment: Intravitreal Antibiotic Injection, Pars Plana Vitrectomy

CompletedNot Applicable

Effectiveness and Safety of 0.5% Moxifloxacin Hydrochloride Ophthalmic Solution in Perioperative Sterilization in Patien…

This is a non-interventional, uncontrolled, prospective, multicenter, post marketing surveillance study.

India102 participantsStarted 2024-01-27

Treatment: Moxifloxacin hydrochloride ophthalmic solution

UnknownNot Applicable

Ozurdex Endophtamitis Cohort, Prognostic Assessment at 12 Months

OZURDEX endophthalmitis is a rare and potentially very serious pathology. Different treatments can be carried out early and change the functional prognosis of t…

France8 participantsStarted 2023-06-05

Treatment: Visual acuity analysis, Intraocular pressure analysis

CompletedNot Applicable

A Study of the Incidence of Intraocular Inflammation and Suspected Endophthalmitis Among Patients Treated With Afliberce…

Specific study objectives include: * To describe patient and provider characteristics for aflibercept patients and aflibercept user injections by aflibercept d…

United States155,413 participantsStarted 2022-09-16

Treatment: Non Applicable

UnknownNot Applicable

Endophthalmitis Post Intravitreal Injections

Intravitreal injection (IVI) is an ophthalmological procedure used worldwide to treat ocular conditions. Its use has been steadily increasing for several years,…

Canada310 participantsStarted 2020-03-01

Treatment: Tap and Inject (TAI), Pars Plana Vitrectomy (PPV)

CompletedPhase 4

A Two Chemoprophylaxis Approaches After Phacoemulsification Surgery

Post cataract surgery bacterial endophthalmitis is a rare but the most devastating complication with a poor visual outcome. The preferred pattern of chemoproph…

Location not specified1,000 participantsStarted 2016-10-01

Treatment: Moxifloxacin hydrochloride 0.5% eye drops, Dexamethasone 0.1% eye drops