Drug Overdose

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Drug Overdose trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 26 trials

RecruitingPhase 4

NCT06429436

Vending Machine Naloxone Distribution for Your Community (VENDY)

Vending machines are an innovative strategy shown to increase access to naloxone, a medication used to reverse opioid overdose. The aim of this proposal is to s…

United States4,000 participantsStarted 2024-06-01

Treatment: VENDY

RecruitingNot Applicable

NCT06768814

Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data

The study is a quasi-experimental investigation of a sub-acute stabilization center (SASC) for people who have had or are at risk for having an opioid overdose…

United States40,000 participantsStarted 2024-12-15

Treatment: Sub-acute stabilization

RecruitingPhase 2/3

NCT06633900

Naltrexone for Overdose Prevention

The goal of this clinical trial is to see if an injectable medicine called naltrexone can prevent fentanyl overdose deaths in people who use other drugs (cocain…

United States100 participantsStarted 2025-04-10

Treatment: IM naltrexone, Usual Care

RecruitingNot Applicable

NCT07541417

Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

This study will provide longitudinal data for 6-months on a target sample of patients with Opioid Use Disorder (OUD) recruited from Prisma Health Mobile Health…

United States750 participantsStarted 2026-04-08

Treatment: Certified Peer Support Specialist Intervention

RecruitingNot Applicable

NCT06573476

Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform

The study aims to adapt an existing Cultural Structural Humility (CSH) training into a video format for peer recovery coaches (PRCs) and refine an AI-driven tex…

United States180 participantsStarted 2025-11-25

Treatment: PRC supported text + AI driven CSDH-enhanced text, AI driven CSDH-enhanced text only

RecruitingPhase 3

NCT07524972

Antenatal Magnesium Sulphate in High-Risk Preterm Patients

The goal of this clinical trial is to evaluate whether antenatal magnesium sulphate reduces the risk of cerebral palsy in infants born to women at high risk of…

Egypt138 participantsStarted 2026-05-01

Treatment: Magnesium sulfate, Placebo

All recent trials (100 shown)

CompletedNot Applicable

NCT06609278

THRIVE: Culturally AdapTed Harm Reduction Intervention

The goal of this study is to develop and test a culturally adapted harm reduction intervention among Black adults who misuse opioids and/or stimulants. The ques…

United States57 participantsStarted 2025-04-02

Treatment: harm reduction intervention

Active — Not RecruitingNot Applicable

NCT05657106

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

This study will test the effectiveness, implementation outcomes, and cost effectiveness of a community-tailored, harm reduction kiosk in reducing HIV, hepatitis…

United States752 participantsStarted 2023-03-06

Treatment: Harm reduction kiosk

Drug Overdose

Trial phase breakdown

Trial status

Actively recruiting — 26 trials

Vending Machine Naloxone Distribution for Your Community (VENDY)

Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data

Naltrexone for Overdose Prevention

Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform

Antenatal Magnesium Sulphate in High-Risk Preterm Patients

All recent trials (100 shown)

THRIVE: Culturally AdapTed Harm Reduction Intervention

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

Trial phase breakdown

Trial status

Actively recruiting — 26 trials

Vending Machine Naloxone Distribution for Your Community (VENDY)

Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data

Naltrexone for Overdose Prevention

Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform

Antenatal Magnesium Sulphate in High-Risk Preterm Patients

All recent trials (100 shown)

THRIVE: Culturally AdapTed Harm Reduction Intervention

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

Permanent Supportive Housing Overdose Prevention+ Study

Permanent Supportive Housing Overdose Prevention

Phase I/II Study of [225Ac]Ac-PSMA-R2 in PSMA-positive Prostate Cancer, With/Without Prior 177Lu-PSMA RLT

Pharmacokinetic (PK) Evaluation of Nalmefene Formulations

Evaluation of Clinical Decision Support in Opioid Tapering

Kentucky Women's Justice Community Overdose Innovation Network - Phase II

Behavioral Safety and Fentanyl Education: BSAFE

A Bundled Intervention to End Opioid Overdoses

Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy Adults

Patient and Caregiver Attitudes and Beliefs Regarding Prescription of Intranasal Naloxone Spray for Opioid Overdose

Justice Community Overdose Innovation Network II TCU Hub

Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Diso…

Remote Fentanyl Test Strip Distribution and Education to Prevent Drug Overdose

Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary Care

The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study

Supporting Treatment Access and Recovery Through Linkage and Support

Preventing Overdose Using Information and Data From the Environment

Prevention of Opioid Misuse and Overdose Deaths Among Hispanic/Latinx Adolescents: A Family-based Perspective