Central Diabetes Insipidus

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Central Diabetes Insipidus trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 15 trials

RecruitingPhase 2

NCT06036004

Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus

This randomized, placebo-controlled, double-blind trial aims to investigate intranasal OXT as a novel therapeutical option in central diabetes insipidus (cDI) t…

Germany, Netherlands, Switzerland112 participantsStarted 2024-01-08

Treatment: Intranasal OXT, Placebo nasal spray

RecruitingEarly Phase 1

NCT07568509

Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease

An open-labeled, interventional pilot trial, 10 youth with AVP-D and 10 PD matched for age, sex, and BMI will be recruited from Pediatric Endocrinology and Neur…

United States20 participantsStarted 2026-05

Treatment: Norethindrone Acetate-Ethinyl Estradiol

RecruitingPhase 2

NCT06368817

A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

This phase II trial studies how well lower dose radiotherapy after chemotherapy (Carboplatin \& Etoposide) works in treating children with central nervous syste…

United States240 participantsStarted 2024-10-22

Treatment: 3-Dimensional Conformal Proton Radiation Therapy, 3-Dimensional Conformal Radiation Therapy

RecruitingNot Applicable

NCT06742060

The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU

Central diabetes insipidus (CDI),a disease caused by the decrease of AVP (a hormone involved in the control of water-electrolyte balance ) secretion and charace…

China100 participantsStarted 2024-11-22

Treatment: serum copeptin levels

RecruitingNot Applicable

NCT07276152

Plasma Oxytocin Changes in Response to Music Modified by Sonic Augmentation Technology

The investigator aim to investigate wheather music modified by sonic augmentation technology can produce increasing oxytocin levels with minimal to no side effe…

Switzerland22 participantsStarted 2026-01-09

Treatment: sonic augmentation technology

RecruitingNot Applicable

NCT07361263

Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency

The PHOENIX study aims to investigate whether oral estradiol valerate (EV) and ethinylestradiol (EE) can stimulate oxytocin (OXT) and neurophysin-1 (NP-1) relea…

Switzerland28 participantsStarted 2026-01-09

Treatment: estradiol valerate, esthinylestradiol

All recent trials (64 shown)

Not Yet RecruitingNot Applicable

NCT07569861

Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome

The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the curr…

Switzerland144 participantsStarted 2026-07

Treatment: Mannitol, Hypertonic Saline

CompletedPhase 2

NCT05190744

Probenecid (PB) to Treat Hereditary Nephrogenic Diabetes Insipidus (NDI), ADPKD Treated With Tolvaptan, and Severely Pol…

The purpose of this research is to study the effectiveness and safety of the medication PB in slowing the frequent urination related to tolvaptan as long-term t…

United States36 participantsStarted 2022-09-01

Treatment: PB

Central Diabetes Insipidus

Trial phase breakdown

Trial status

Actively recruiting — 15 trials

Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus

Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease

A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU

Plasma Oxytocin Changes in Response to Music Modified by Sonic Augmentation Technology

Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency

All recent trials (64 shown)

Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome

Probenecid (PB) to Treat Hereditary Nephrogenic Diabetes Insipidus (NDI), ADPKD Treated With Tolvaptan, and Severely Pol…

Trial phase breakdown

Trial status

Actively recruiting — 15 trials

Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus

Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease

A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU

Plasma Oxytocin Changes in Response to Music Modified by Sonic Augmentation Technology

Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency

All recent trials (64 shown)

Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome

Probenecid (PB) to Treat Hereditary Nephrogenic Diabetes Insipidus (NDI), ADPKD Treated With Tolvaptan, and Severely Pol…

Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)

Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study)

Evaluation of Discriminating Power of Two Biomarkers in the Evaluation of Cerebral Lesions Due to Head Injuries in Infan…

Baby Detect : Genomic Newborn Screening

Arginin-stimulated Copeptin in Polyuria-polydipsia Syndrome in Children

Copeptin Kinetics in Critically Ill Patients With Posterior Reversible Encephalopathy Syndrome

Plasma Copeptin in Response to Oral Urea in Healthy Adults and Patients With Polyuria-polydipsia Syndrome

Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)

Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study)

Electrophysiology of the Human Pituitary Gland

Efficacy, Safety, and Tolerability Study of Oral Full-Spectrum MicrobiotaTM (CP101) in Subjects With Recurrent C. Diff

Open-Label Extension of CP101 Trials Evaluating Oral Full-Spectrum Microbiota™ (CP101) in Subjects With Recurrence of Cl…

Fecal Microbiota Transplantation for Early Clostridioides Difficile Infection

Copeptin as a Biomarker for Central Diabetes Insipidus Development Following Pituitary Surgery

Copeptin After a Subcutaneous Stimulation With Glucagon in Adults

Circulating Oxytocin Changes in Response to the Oxytocin System Stimulator MDMA in Patients With Diabetes Insipidus and…

AMCPR (Augmented-Medication CardioPulmonary Resuscitation) Trial for OHCA

Predictive Value of Copeptin in the Diagnosis of Acute Ischemic Stroke