CDKL5 Deficiency Disorder (CDD)

Clinical trial pipeline · Data from ClinicalTrials.gov

See which CDKL5 Deficiency Disorder (CDD) trials may be worth asking about

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 1 trial

RecruitingNot Applicable

NCT05558371

International CDKL5 Clinical Research Network

Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epi…

United States, Australia1,000 participantsStarted 2021-02-15Updated 2023-12-06

Treatment: No intervention.

All recent trials (9 shown)

Not Yet RecruitingPhase 3

NCT05249556

Double-blind, Randomized, Placebo-controlled Trial of Ganaxolone in CDKL5 Deficiency Patients 6 Months to Less Than 2 Ye…

This study will assess the efficacy, safety, and tolerability of ganaxolone (GNX) compared with placebo (PBO) as adjunctive therapy to the participant's standar…

Location not specified20 participantsStarted 2027-03Updated 2026-08-05

Treatment: Ganaxolone, Placebo

Active — Not RecruitingPhase 3

NCT05064878

A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.

This is a Phase 3 Study to examine the efficacy and safety of ZX008 in children and adults with cyclin-dependent kinase like-5 (CDKL5) deficiency disorder (CDD)…

United States, Austria +12 more87 participantsStarted 2022-03-08

CDKL5 Deficiency Disorder (CDD)

Trial phase breakdown

Trial status

Actively recruiting — 1 trial

International CDKL5 Clinical Research Network

All recent trials (9 shown)

Double-blind, Randomized, Placebo-controlled Trial of Ganaxolone in CDKL5 Deficiency Patients 6 Months to Less Than 2 Ye…

A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.

Trial phase breakdown

Trial status

Actively recruiting — 1 trial

International CDKL5 Clinical Research Network

All recent trials (9 shown)

Double-blind, Randomized, Placebo-controlled Trial of Ganaxolone in CDKL5 Deficiency Patients 6 Months to Less Than 2 Ye…

A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.

International CDKL5 Registry

Observational Study in Patients With Cyclin-dependent Kinase-like 5 Deficiency Disorder

Targeting the Gut to Improve Seizure Control in CDKL5 Deficiency Disorder (CDD)

Fenfluramine in CDKL5 Deficiency Disorder (CDD)

Study of Adjunctive Ganaxolone Treatment in Children and Young Adults With CDKL5 Deficiency Disorder

A Multicenter, Open-label, Pilot Study of Soticlestat (TAK-935/OV935) in Participants With 15Q Duplication Syndrome (Dup…