Adult Gliomas, Mixed

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Adult Gliomas, Mixed trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 4 trials

RecruitingPhase 1

NCT04185038

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliom…

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4+ and CD8+ T cells lentivirally transduced to express a…

United States90 participantsStarted 2019-12-11

Treatment: SCRI-CARB7H3(s); B7H3-specific chimeric antigen receptor (CAR) T cel

RecruitingPhase 1

NCT07087002

GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults

This is a single-site, open-label Phase 1 clinical trial evaluating the feasibility, safety, and preliminary activity of autologous GPC2-targeted chimeric antig…

United States18 participantsStarted 2025-08-28

Treatment: GPC2-CAR T cells, Fludarabine

RecruitingEarly Phase 1

NCT05851378

Hyperpolarized Carbon-13 Alpha-ketoglutarate Imaging in IDH Mutant Glioma

This study will investigate the use of hyperpolarized (HP) carbon-13 (13C) alpha-ketoglutarate (aKG) (HP 13C-aKG) to characterize tumor burden in participants w…

United States40 participantsStarted 2023-04-11

Treatment: Hyperpolarized Carbon 13 Alpha-ketoglutarate (HP C13-aKG), Magnetic Resonance Image (MRI)

RecruitingPhase 2

NCT05180825

Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy

Pediatric low-grade glioma (PLGG) is a heterogeneous group of WHO grade I and II brain tumors, associated with a 10-year overall survival of 90%. It is the most…

France134 participantsStarted 2022-05-05

Treatment: Trametinib, Vinblastine

All recent trials (100 shown)

Active — Not RecruitingPhase 1

NCT00268385

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

This phase I trial is studying the side effects and best dose of vorinostat when given together with temozolomide in treating patients with malignant gliomas. D…

United States83 participantsStarted 2005-12-16

Treatment: Laboratory Biomarker Analysis, Pharmacological Study

TerminatedNot Applicable

NCT05934630

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

Recent advances in technology have allowed for the detection of cell-free DNA (cfDNA). cfDNA is tumor DNA that can be found in the fluid that surrounds the brai…

United States57 participantsStarted 2023-07-12

Adult Gliomas, Mixed

Trial phase breakdown

Trial status

Actively recruiting — 4 trials

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliom…

GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults

Hyperpolarized Carbon-13 Alpha-ketoglutarate Imaging in IDH Mutant Glioma

Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy

All recent trials (100 shown)

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

Trial phase breakdown

Trial status

Actively recruiting — 4 trials

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliom…

GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults

Hyperpolarized Carbon-13 Alpha-ketoglutarate Imaging in IDH Mutant Glioma

Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy

All recent trials (100 shown)

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas

A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Particip…

B7-H3.CD28Z.CART in CNS Neoplasms

Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in…

HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma

Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diag…

131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young Adults

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas

Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Re…

Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

Temozolomide and Radiation Therapy in Treating Patients With Gliomas

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children…

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT