Histoplasmosis Induction and Consolidation Therapy Factorial Randomized Clinical Trial (Histo-FACT)

Inclusion Criteria: * Age ≥18 years * Hospitalized with suspected histoplasmosis b * Diagnosis of confirmed or probable histoplasmosis (via positive Histoplasma antigen test, culture, histopathology or microscopy) * Provision of Informed Consent by participant or surrogate c Exclusion Criteria: * Previous diagnosis of histoplasmosis * Pregnant persons (all persons who could potentially be pregnant will have a pregnancy test prior to enrollment, and if negative, must agree to contraception for the duration of the study) * Breastfeeding and unable to stop for the duration of the study * Renal impairment (serum creatinine or blood urea nitrogen (BUN) \>2.0x upper limit of normal) * Allergy or contraindication to a study medicine * More than one dose of an amphotericin product in the prior 7 days * Suspected central nervous system involvement of histoplasmosis * Likely to die in the next 48 hours in the judgment of the investigator * Unlikely to follow up for the duration of the study in the judgement of the investigator * Significant drug-drug interaction with itraconazole or posaconazole (such as rifampin in persons with TB) * Current diagnosis of cryptococcosis or leishmaniasis * QTc interval consistently \>450 milliseconds * Prisoners * Unable to take oral medications