EVT in Acute Basilar Artery Occlusion With Large Infarction Core (NCT07090941) | Clinical Trial Compass
RecruitingNot Applicable
EVT in Acute Basilar Artery Occlusion With Large Infarction Core
China348 participantsStarted 2025-08-01
Plain-language summary
A multicenter, prospective, open-label, blinded endpoint, randomized controlled trial designed to evaluate the efficacy and safety of best medical management (BMM) combined with endovascular treatment (EVT) versus BMM alone in acute basilar artery occlusion (BAO) patients with large infarct cores.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 1\. Age ≥18 years. 2. Symptoms and signs consistent with basilar artery ischemia. 3. Basilar artery or vertebral artery occlusion confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA), digital subtraction angiography (DSA); if vertebral artery occlusion is present, it must completely obstruct blood flow to the basilar artery.
4\. POST-NIHSS score ≥10 at randomization. 5. Time from symptom onset to randomization ≤24 hours (symptom onset defined as last known well time).
6\. pc-ASPECTS of 3-5 on CT/MRI (for patients aged \<80 years) or pc-ASPECTS of 3-7 (for patients aged ≥80 years).
7\. Willingness of the patient or legally authorized representative to comply with protocol requirements and data collection procedures, with documented informed consent.
Exclusion Criteria:
* 1\. Pre-stroke modified Rankin Scale (mRS) score \>2. 2. Factors in the target vessel that are expected to prevent completion of endovascular treatment.
3\. Concurrent anterior and posterior circulation strokes or multivessel occlusions.
4\. Significant mass effect with imaging or clinical signs of obstructive hydrocephalus or tonsillar herniation.
5\. Basilar artery occlusion confirmed as chronic by prior imaging or investigator judgment.
6\. Presence of untreated intracranial aneurysms, intracranial tumors (except small meningiomas), or intracranial vascular malformations.
7\. Intracranial hemorrhage within the past 6 months…
What they're measuring
1
Shift analysis of the improvement trend in modified Rankin Scale (mRS) scores at 90 (±7) days after randomization.
Timeframe: 90 (±7) days after procedure
Trial details
NCT IDNCT07090941
SponsorThe First Affiliated Hospital of Hainan Medical University